Antibody to transforming growth factor-beta ameliorates tubular apoptosis in unilateral ureteral obstruction.
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Summary
It is strongly suggested that an antibody to TGF-beta is a promising agent to prevent renal tubular fibrosis and apoptosis in UUO.
- Type
- article
- Published
- 2000-12-01
- Cited by
- 338
- References
- 36
- Access
- Open access
- OpenAlex
- https://openalex.org/W2032667836
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:25251994
Keywords
Kidney, Immunostaining, Apoptosis, Fibrosis, Transforming growth factor beta
References
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- Suppression of experimental glomerulonephritis by antiserum against transforming growth factor β1
- Repeating modular structure of the fibronectin gene: relationship to protein structure and subunit variation.
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- Rapid quantitation of apoptosis in pure and heterogeneous cell populations using flow cytometry.
- Spontaneously increased production of nitric oxide and aberrant expression of the inducible nitric oxide synthase in vivo in the transforming growth factor beta 1 null mouse
- An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct.
- Cell apoptosis and proliferation in experimental chronic obstructive uropathy.
- Inhibition of Corneal Fibrosis by Topical Application of Blocking Antibodies to TGFβ in the Rabbit
- Cell cycle control and cancer.
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- Growth factors and apoptosis in neonatal ureteral obstruction.
- Transforming growth factor-beta 1 inhibits the production of IL-8 and the transmigration of neutrophils through activated endothelium.
- Immediate early up-regulation of bax expression by p53 but not TGF beta 1: a paradigm for distinct apoptotic pathways.
- Relationship between renal function and histological changes found in renal-biopsy specimens from patients with persistent glomerular nephritis.
- Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
Cited by
- Synthesis and biological evaluation of 5-(pyridin-2-yl)thiazoles as transforming growth factor-beta type1 receptor kinase inhibitors.
- Mast cell activation and degranulation promotes renal fibrosis in experimental unilateral ureteric obstruction.
- Microvascular disease and endothelial dysfunction in chronic kidney diseases: Therapeutic implication
- Short Hairpin RNA Knockdown of Connective Tissue Growth Factor by Ultrasound-Targeted Microbubble Destruction Improves Renal Fibrosis.
- Increased Tbx1 expression may play a role via TGFβ-Smad2/3 signaling pathway in acute kidney injury induced by gentamicin.
- Mitogen activated protein kinases in renal fibrosis.
- DISSECTION OF NOVEL PATHWAYS LEADING TO PODOCYTE DYSFUNCTION AND PROTEINURIA
- Étude de l’expression de « Bcl-2 modifying factor » (Bmf) et son implication dans la néphropathie diabétique
- Role of the immune system during the development of acute and chronic renal disease
- Early detection of endothelial injury and dysfunction in conjunction with correction of hemodynamic maladjustment can effectively restore renal function in type 2 diabetic nephropathy
- Mediators and mechanisms of heat shock protein 70 based cytoprotection in obstructive nephropathy
- BMP-7 Signaling and its Critical Roles in Kidney Development, the Responses to Renal Injury, and Chronic Kidney Disease.
- Congenital urinary tract obstruction: Proceedings of the State-Of-The-Art Strategic Planning Workshop—National Institutes of Health, Bethesda, Maryland, USA, 11–12 March 2002
- PPAR-γ agonist attenuates renal interstitial fibrosis and inflammation through reduction of TGF-β
- Ureter, the Guardian Angel of Nephron: The Impact of Pelvicalyceal System on Apoptotic Activity in an Experimental Obstructive Uropathy Model
- Alteration in the phenotype of macrophages in the repair of renal interstitial fibrosis in mice
- Role of angiotensin II in chronic ureteral obstruction.
- Immunotherapy with Injectable Hydrogels to Treat Obstructive Nephropathy
- Angiotensin II type I antagonist prevents pulmonary metastasis of murine renal cancer by inhibiting tumor angiogenesis.
- Obstructive acute renal failure: Treatment and prognostic factors
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