Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? Findings in 356,222 primary screenees of the Multiple Risk Factor Intervention Trial (MRFIT).
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Summary
The data of high precision show that the relationship between serum cholesterol and CHD is not a threshold one, with increased risk confined to the two highest quintiles, but rather is a continuously graded one that powerfully affects risk for the great majority of middle-aged American men.
- Type
- article
- Published
- 1986-11-28
- Cited by
- 2,170
- References
- 22
- OpenAlex
- https://openalex.org/W2032525547
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:38957414
Keywords
Medicine, Myocardial infarction, Cholesterol, Internal medicine, Serum cholesterol
References
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- Serum cholesterol--the knave of hearts and the joker.
- Changing trends in coronary heart disease mortality; possible explanations.
- Rationale of the diet-heart statement of the American Heart Association. Report of the AHA nutrition committee.
- Continuous flow paper electrophoresis of the anticoagulant fraction of incubated fibrinogen
- Primary prevention of the atherosclerotic diseases
- Coronary heart disease: doing the "right things".
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- Hyperlipidemia after cardiac transplantation: be aware and possibly wary of drug therapy for lowering of serum lipids.
- Stratifying the patient at risk from coronary disease: new insights from the Framingham Heart Study.
- Stellenwert der LDL-Apherese in der Behandlung der koronaren Herzerkrankung
- Heterogeneity in survival analysis.
- Androgenic anabolic steroid abuse and the cardiovascular system.
- Crossover trial of simvastatin versus pravastatin in patients with primary hypercholesterolemia.
- Assessment of cardiovascular risk by use of multiple-risk-factor assessment equations: a statement for healthcare professionals from the American Heart Association and the American College of Cardiology.
- Clinical goals and performance measures for cholesterol management in secondary prevention of coronary heart disease.
- Serum levels of high-density lipoprotein phospholipids correlate inversely with severity of angiographically defined coronary artery disease.
- Low-density lipoprotein receptor gene mutation analysis and clinical correlation in Belgian hypercholesterolaemics.
- Screening for traditional risk factors for cardiovascular disease: a review for oral health care providers.
- Cost-effectiveness of a family and DNA based screening programme on familial hypercholesterolaemia in The Netherlands.
- Cardiovascular risk prediction in the Netherlands
- Calculated low density lipoprotein cholesterol levels frequently underestimate directly measured low density lipoprotein cholesterol determinations in patients with serum triglyceride levels < or =4.52 mmol/l: an analysis comparing the LipiDirect magnetic LDL assay with the Friedewald calculation.
- Protective effect of dietary curcumin and capsaicin on induced oxidation of low‐density lipoprotein, iron‐induced hepatotoxicity and carrageenan‐induced inflammation in experimental rats
- The pathogenesis of atherosclerosis and new opportunities for treatment and prevention.
- PROCEED: Prospective Obesity Cohort of Economic Evaluation and Determinants: baseline health and healthcare utilization of the US sample *
- Dietary prevention of coronary artery disease. How to help patients modify eating habits and reduce cholesterol.
- Is the use of cholesterol in mortality risk algorithms in clinical guidelines valid? Ten years prospective data from the Norwegian HUNT 2 study
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