Cationic lipid-DNA complexes in gene delivery: from biophysics to biological applications.
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Summary
This review focuses on the various parameters that are considered to be crucial to optimize the use of cationic lipid-DNA complexes for gene therapy purposes, from the biophysical aspects underlying the formation of the complexes to the different biological barriers that need to be surpassed for gene expression to occur.
- Type
- review
- Published
- 2001-04-25
- Cited by
- 346
- References
- 85
- OpenAlex
- https://openalex.org/W2031181465
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:9292707
Keywords
Gene delivery, Genetic enhancement, Transfection, Nucleic acid, Computational biology
References
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- LIPOSOMES in GENE DELIVERY
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- Electrostatic and structural properties of complexes involving plasmid DNA and cationic lipids commonly used for gene delivery.
- Electrostatic parameters of cationic liposomes commonly used for gene delivery as determined by 4-heptadecyl-7-hydroxycoumarin.
- A peptide nucleic acid–nuclear localization signal fusion that mediates nuclear transport of DNA
- Enhanced gene delivery and mechanism studies with a novel series of cationic lipid formulations.
- Evaluation and optimization of different cationic liposome formulations for in vivo gene transfer.
- Characterization of Cationic Liposome-Mediated Gene Transfer In Vivo by Intravenous Administration
- Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.
- Potentiation of cationic liposome-mediated gene delivery by polycations.
- Biological barriers to cellular delivery of lipid-based DNA carriers.
- Gene delivery: a single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus.
- Recent developments in medical applications of liposomes: sterically stabilized liposomes in cancer therapy and gene delivery in vivo
- Time-dependent maturation of cationic liposome–DNA complex for serum resistance
- Stabilization of cationic liposome‐plasmid DNA complexes by polyamines and poly(ethylene glycol)‐phospholipid conjugates for efficient in vivo gene delivery
- Biophysical characterization of cationic lipid: DNA complexes.
- Receptor Ligand-Facilitated Gene Transfer: Enhancement of Liposome-Mediated Gene Transfer and Expression by Transferrin
- Basis of Pulmonary Toxicity Associated with Cationic Lipid-Mediated Gene Transfer to the Mammalian Lung
Cited by
- Protection of oligonucleotides against nucleases by pegylated and non-pegylated liposomes as studied by fluorescence correlation spectroscopy.
- Nonviral gene delivery: What we know and what is next
- Analysis of cationic-lipid-plasmid-DNA complexes.
- Nucleic acids in therapy.
- RNA interference of avian influenza virus H5N1 by inhibiting viral mRNA with siRNA expression plasmids.
- Flow cytometry and live confocal analysis for the evaluation of the uptake and intracellular distribution of FITC-ODN into HaCaT cells
- Virus-Mimetic Cytoplasm-Cleavable Magnetic/Silica Nanoclusters for Enhanced Gene Delivery to Mesenchymal Stem Cells
- Estudios sobre translocación de complejos DNA-liposomas a través de membranas celulares para mejorar la transfección en células eucariontes (Revisión)
- Targeted lipoplexes for siRNA delivery.
- Stabilisation, modification, delivery and treatment of phospholipid based vesicles for applications in advanced wound management
- Site directed drug delivery by non-viral mode
- Preparation of lipid:peptide:DNA (LPD) nanoparticles and their use for gene transfection.
- Genetic nanomedicine: gene delivery by targeted lipoplexes.
- Impacts of nanomedicines in ocular pharmacotherapy.
- Serum-resistant gene transfer to oral cancer cells by Metafectene and GeneJammer: application to HSV-tk/ganciclovir-mediated cytotoxicity.
- Complexation of siRNA and pDNA with cationic liposomes: the important aspects in lipoplex preparation.
- Gene therapy for oral cancer: efficient delivery of a 'suicide gene' to murine oral cancer cells in physiological milieu.
- Cationic liposomes/lipids for oligonucleotide delivery: application to the inhibition of tumorigenicity of Kaposi's sarcoma by vascular endothelial growth factor antisense oligodeoxynucleotides.
- DNA-Pharmaceuticals: Formulation and Delivery in Gene Therapy, DNA Vaccination and Immunotherapy
- Live Cell Characterization of DNA Aggregation Delivered through Lipofection
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