Transient Receptor Potential Canonical-3 Channel–Dependent Fibroblast Regulation in Atrial Fibrillation
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Summary
TRPC3 channels regulate cardiac fibroblast proliferation and differentiation, likely by controlling the Ca2+ influx that activates extracellular signal-regulated kinase signaling and is a novel potential therapeutic target.
- Type
- article
- Published
- 2012-09-19
- Cited by
- 60
- References
- 43
- Access
- Open access
- OpenAlex
- https://openalex.org/W2030826846
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:266020807
Keywords
TRPC3, Fibroblast, NFAT, Extracellular, Molecular biology
References
- Ca2+ influx and protein scaffolding via TRPC3 sustain PKCβ and ERK activation in B cells
- C‐type natriuretic peptide activates a non‐selective cation current in acutely isolated rat cardiac fibroblasts via natriuretic peptide C receptor‐mediated signalling
- LTRPC7 is a Mg·ATP-regulated divalent cation channel required for cell viability
- Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound
- A synthetic inhibitor of the mitogen-activated protein kinase cascade.
- From guidelines to bench: implications of unresolved clinical issues for basic investigations of atrial fibrillation mechanisms.
- TRPC3 and TRPC6 are essential for angiotensin II‐induced cardiac hypertrophy
- Atrial fibrosis: mechanisms and clinical relevance in atrial fibrillation.
- “Early” Class III Drugs for the Treatment of Atrial Fibrillation: Efficacy and Atrial Selectivity of AVE0118 in Remodeled Atria of the Goat
- Angiotensin II–Induced Extracellular Signal–Regulated Kinase 1/2 Activation Is Mediated by Protein Kinase C&dgr; and Intracellular Calcium in Adult Rat Cardiac Fibroblasts
- Atrial and ventricular fibrosis induced by atrial fibrillation: evidence to support early rhythm control.
- TRPC channels are necessary mediators of pathologic cardiac hypertrophy
- Functional characterization and physiological relevance of the TRPC3/6/7 subfamily of cation channels
- Cloning of short hairpin RNAs for gene knockdown in mammalian cells
- TRPC channels promote cerebellar granule neuron survival
- The TRPC3 channel has a large internal chamber surrounded by signal sensing antennas.
- Omega-3 Polyunsaturated Fatty Acids Prevent Atrial Fibrillation Associated With Heart Failure but Not Atrial Tachycardia Remodeling
- TRP channels as cellular sensors
- TRPC3 Mediates T-cell Receptor-dependent Calcium Entry in Human T-lymphocytes*
- Recent advances in the molecular pathophysiology of atrial fibrillation.
Cited by
- Atrial remodeling and atrial fibrillation: recent advances and translational perspectives.
- Intracellular Signaling of Cardiac Fibroblasts
- Prediction of new onset atrial fibrillation through P wave analysis in 12 lead ECG.
- Integrated analyses identify the involvement of microRNA-26a in epithelial–mesenchymal transition during idiopathic pulmonary fibrosis
- MicroRNA-26 governs profibrillatory inward-rectifier potassium current changes in atrial fibrillation.
- The involvement of TRPC3 channels in sinoatrial arrhythmias
- TRPC3 contributes to regulation of cardiac contractility and arrhythmogenesis by dynamic interaction with NCX1
- Cellular and Molecular Electrophysiology of Atrial Fibrillation Initiation, Maintenance, and Progression
- Gain-of-function Mutations in Transient Receptor Potential C6 (TRPC6) Activate Extracellular Signal-regulated Kinases 1/2 (ERK1/2)*
- MicroRNA Regulation and Cardiac Calcium Signaling: Role in Cardiac Disease and Therapeutic Potential
- Mechanistic inquiry into the role of tissue remodeling in fibrotic lesions in human atrial fibrillation.
- The value of basic research insights into atrial fibrillation mechanisms as a guide to therapeutic innovation: a critical analysis.
- Electrophysiological and molecular mechanisms of paroxysmal atrial fibrillation
- Untersuchungen zur Funktion der MicroRNAs miR-199a/b-3p und miR-223 im kardiovaskulären System
- MicroRNAs in Atrial Fibrillation.
- Cardiac fibroblasts
- Translational Challenges in Atrial Fibrillation
- Cardiovascular aging: the unveiled enigma from bench to bedside
- TRPC3 as a Target of Novel Therapeutic Interventions
- Clarity and controversy around rate control in AF, the orphan child in AF therapeutics.
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