Invited commentary: insulin resistance syndrome? Syndrome X? Multiple metabolic syndrome? A syndrome at all? Factor analysis reveals patterns in the fabric of correlated metabolic risk factors.
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Summary
Factor analysis of data on 322 healthy elderly people from the Cardiovascular Health Study confirmed findings from a dozen prior studies that as many as four distinct physiologic domains comprise the syndrome, with a unifying role for markers of insulin resistance.
- Type
- review
- Published
- 2000-11-15
- Cited by
- 435
- References
- 29
- Access
- Open access
- OpenAlex
- https://openalex.org/W2029897333
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:332835
Keywords
Insulin resistance, Metabolic syndrome, Medicine, Risk factor, Inflammation
References
- Insulin resistance syndrome predicts coronary heart disease events in elderly nondiabetic men.
- Hyperinsulinemia, hyperglycemia, and impaired hemostasis: the Framingham Offspring Study.
- Fibrinogen, a cardiovascular risk factor
- Prevalence and correlates of the insulin resistance syndrome among Native Americans. The Inter-Tribal Heart Project.
- Cardiovascular risk factors in confirmed prediabetic individuals. Does the clock for coronary heart disease start ticking before the onset of clinical diabetes?
- Low insulin sensitivity is associated with clustering of cardiovascular disease risk factors.
- Risk Variable Clustering in the Insulin Resistance Syndrome: The Framingham Offspring Study
- Clustering of procoagulation, inflammation, and fibrinolysis variables with metabolic factors in insulin resistance syndrome.
- Hyperinsulinemia cluster predicts the development of type 2 diabetes independently of family history of diabetes.
- Postchallenge Glucose Concentration and Coronary Heart Disease in Men of Japanese Ancestry: Honolulu Heart Program
- Does insulin resistance unite the separate components of the insulin resistance syndrome? Evidence from the Miami Community Health Study.
- Associations of smoking, alcohol and physical activity with risk factors for coronary heart disease and diabetes in the first follow‐up cohort of the Heart Disease and Diabetes Risk Indicators in a Screened Cohort study (HDDRISC‐1)
- Cardiovascular risk factors clustering features of insulin resistance syndrome (Syndrome X) in a biracial (Black-White) population of children, adolescents, and young adults: the Bogalusa Heart Study.
- Clustering of dyslipidemia, hyperuricemia, diabetes, and hypertension and its association with fasting insulin and central and overall obesity in a general population. Atherosclerosis Risk in Communities Study Investigators.
- Applied Multivariate Statistics for the Social Sciences
- Involvement of the hemostatic system in the insulin resistance syndrome. A study of 1500 patients with angina pectoris. The ECAT Angina Pectoris Study Group.
- Factors of the metabolic syndrome: baseline interrelationships in the first follow-up cohort of the HDDRISC Study (HDDRISC-1). Heart Disease and Diabetes Risk Indicators in a Screened Cohort.
- Body mass index, diabetes, and C-reactive protein among U.S. adults.
- Clustering of metabolic factors and coronary heart disease.
- Prevalence of insulin resistance in metabolic disorders: the Bruneck Study.
Cited by
- The relative risk of cardiovascular death among racial and ethnic minorities with metabolic syndrome: data from the NHANES-II mortality follow-up.
- Identifying risk of type 2 diabetes : epidemiologic perspectives from biomarkers to lifestyle
- The WHO and NCEP/ATPIII Definitions of the Metabolic Syndrome in Postmenopausal Women: Are They So Different?
- [Dementia and diabetes mellitus].
- Short-Term High-Fat-and-Fructose Feeding Produces Insulin Signaling Alterations Accompanied by Neurite and Synaptic Reduction and Astroglial Activation in the Rat Hippocampus
- The Metabolic Syndrome in Children and Adolescents: Shifting the Focus to Cardiometabolic Risk Factor Clustering
- The Inter-Related Biomarkers of Cardio-Metabolic and Renal Disease
- Waist Circumference predicting Cardiovascular Disease in Korean Men and Women
- A decision tree-based approach for identifying urban-rural differences in metabolic syndrome risk factors in the adult Korean population
- C-reactive protein level as an independent risk factor of metabolic syndrome in the Korean population. CRP as risk factor of metabolic syndrome.
- The effect on cardiovascular risk factors of migration from rural to urban areas in Peru
- A comparison of the prevalence of the metabolic syndrome in the United States (US) and Korea in young adults aged 20 to 39 years.
- Current Epidemiological Approaches to the Metabolic-Cognitive Syndrome
- A case-control study on insulin resistance, metabolic co-variates & prediction score in non-alcoholic fatty liver disease.
- Dyslipidemia patterns are differentially associated with dietary factors.
- Comparing NR Expression among Metabolic Syndrome Risk Factors
- Obesity-Related Metabolic Syndrome: Investigations into Novel Clinical Markers and Possible Causes
- L-arginine and Alzheimer's disease.
- Metabolic syndrome and high-sensitivity C-reactive protein in Cubans.
- Evidence in Obese Children: Contribution of Hyperlipidemia, Obesity-Inflammation, and Insulin Sensitivity
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