In Vivo Deficiency of Both C/EBPβ and C/EBPε Results in Highly Defective Myeloid Differentiation and Lack of Cytokine Response
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Summary
The phenotype of the bbee mice is distinct from either the bbEE or BBee mice, demonstrating that both transcription factors are crucial for the maturation of neutrophils and macrophages, as well as the innate immune system, and can at least in part compensate for each other in the single knockout mice.
- Type
- article
- Published
- 2010-11-03
- Cited by
- 48
- References
- 42
- Access
- Open access
- OpenAlex
- https://openalex.org/W2028549551
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5952757
Keywords
Haematopoiesis, Bone marrow, Myeloid, Ccaat-enhancer-binding proteins, Biology
References
- The C/EBPβ Isoform 34-kDa LAP Is Responsible for NF-IL-6-Mediated Gene Induction in Activated Macrophages, but Is Not Essential for Intracellular Bacteria Killing1
- A novel temporal expression pattern of three C/EBP family members in differentiating myelomonocytic cells.
- CCAAT/enhancer binding protein epsilon is critical for effective neutrophil-mediated response to inflammatory challenge.
- Lymphoproliferative disorder and imbalanced T‐helper response in C/EBP beta‐deficient mice.
- C/EBPβ Gene Inactivation Causes Both Impaired and Enhanced Gene Expression and Inverse Regulation of IL-12 p40 and p35 mRNAs in Macrophages1
- PU.1 (Spi-1) and C/EBP alpha regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells.
- Macrophage differentiation-specific expression of NF-IL6, a transcription factor for interleukin-6.
- A novel, myeloid transcription factor, C/EBP epsilon, is upregulated during granulocytic, but not monocytic, differentiation.
- Modulation of endocytosis in nuclear factor IL-6(-/-) macrophages is responsible for a high susceptibility to intracellular bacterial infection.
- Redundancy of C/EBPα, -β, and -δ in Supporting the Lipopolysaccharide-Induced Transcription of IL-6 and Monocyte Chemoattractant Protein-1
- A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus.
- Transcriptional regulation of granulocyte and monocyte development
- Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages.
- Impaired response to GM-CSF and G-CSF, and enhanced apoptosis in C/EBPbeta-deficient hematopoietic cells.
- Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice.
- Macrophage functional maturation and cytokine production are impaired in C/EBP epsilon-deficient mice.
- Epigenetic modification of CCAAT/enhancer binding protein alpha expression in acute myeloid leukemia.
- C/EBPepsilon interacts with retinoblastoma and E2F1 during granulopoiesis.
- An essential role for C/EBPbeta in female reproduction.
- C/EBP beta regulation of the tumor necrosis factor alpha gene.
Cited by
- Global Identification of EVI1 Target Genes in Acute Myeloid Leukemia
- Association between CEBPE Variant and Childhood Acute Leukemia Risk: Evidence from a Meta-Analysis of 22 Studies
- Gliadin-mediated production of polyamines by RAW264.7 macrophages modulates intestinal epithelial permeability in vitro.
- C/EBPβ and C/EBPδ transcription factors: Basic biology and roles in the CNS.
- Inflammatory transcription factors as activation markers and functional readouts in immune-to-brain communication.
- A Novel In-Frame Deletion in the Leucine Zipper Domain of C/EBPε Leads to Neutrophil-Specific Granule Deficiency
- CCAAT/Enhancer-binding Protein β Inhibits Proliferation in Monocytic Cells by Affecting the Retinoblastoma Protein/E2F/Cyclin E Pathway but Is Not Directly Required for Macrophage Morphology
- Molecular characterization and expressional affirmation of the beta proteasome subunit cluster in rock bream immune defense
- Regulation of Leukemic Cell Differentiation through the Vitamin D Receptor at the Levels of Intracellular Signal Transduction, Gene Transcription, and Protein Trafficking and Stability
- Identification of candidate genes involved in clinical variability among Tunisian patients with β-thalassemia.
- The transcription factor nuclear factor interleukin 6 mediates pro- and anti-inflammatory responses during LPS-induced systemic inflammation in mice.
- Interferon-γ Inhibits Nonopsonized Phagocytosis of Macrophages via an mTORC1-c/EBPβ Pathway
- The role of EVI1 in myeloid malignancies.
- Nicotinamide treatment ameliorates the course of experimental colitis mediated by enhanced neutrophil-specific antibacterial clearance.
- CEBPE polymorphism confers an increased risk of childhood acute lymphoblastic leukemia: a meta-analysis of 11 case-control studies with 5,639 cases and 10,036 controls
- Association of three polymorphisms in ARID5B, IKZF1 and CEBPE with the risk of childhood acute lymphoblastic leukemia in a Chinese population.
- Differential Control of Mincle-Dependent Cord Factor Recognition and Macrophage Responses by the Transcription Factors C/EBPβ and HIF1α
- Myeloid Neoplasms Associated with t(3;12)(q26.2;P13) Are Clinically Aggressive and Frequently Harbor FLT3 Mutations: A Report of 8 Cases and Review of Literature
- Differential DNA Methylation Analysis without a Reference Genome
- There goes the neighborhood: Assembly of transcriptional complexes during the regulation of metabolism and inflammation by the Glucocorticoid Receptor
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