INTERACTION BETWEEN FIBRATES AND STATINS - METABOLIC INTERACTIONS WITH GEMFIBROZIL

Keywords

Gemfibrozil, Chemistry, Atorvastatin, CYP3A4, Pharmacology

References

• Plasma concentrations of active lovastatin acid are markedly increased by gemfibrozil but not by bezafibrateCarl Kyrklund, Janne T. Backman, Kari T. Kivistö — 2001
• Severe rhabdomyolysis associated with the cerivastin-gemfibrozil combination therapy: report of a case.Tze Kin Lau, D. Richard Leachman, Roberto Lufschanowski — 2001
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• Metabolism and drug interactions of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in transplant patients: are the statins mechanistically similar?Uwe Christians, Wolfgang Jacobsen, Leslie Carstensen Floren — 1998
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• A randomized, double-blind trial comparing the efficacy and safety of pitavastatin versus pravastatin in patients with primary hypercholesterolemia.Yasushi Saitō, Nobuhiro Yamada, Tamio Teramoto — 2002
• NK-104: a novel synthetic HMG-CoA reductase inhibitorKouji Kajinami, Hiroshi Mabuchi, Yasushi Saito — 2000
• Application of radioluminography to off-line counting of radioactivity in high-performance liquid chromatographic eluatesShigeo Baba, Yoshikatsu Terazawa, Hideki KIMATA — 1994
• Hypolipidemic effect of NK-104, a potent HMG-CoA reductase inhibitor, in guinea pigs.Hideo Suzuki, Taro Aoki, Taro Tamaki — 1999
• Rifampin greatly reduces plasma simvastatin and simvastatin acid concentrationsCarl Kyrklund — 2000
• The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor fluvastatin: effect on human cytochrome P-450 and implications for metabolic drug interactions.Volker Fischer, Laurie Johanson, Francis Heitz — 1999

Cited by

• Pharmacokinetic interactions between statins and fibrates.Alberto Corsini, Stefano Bellosta, Michael H. Davidson — 2005
• Effect of Gemfibrozil on the Metabolism of Pitavastatin - Determining the Best Animal Model for Human CYP And UGT ActivitiesHideki Fujino, Takeshi Saito, Y. Tsunenari, — 2004
• Drug interactions with statinsAnida Čaušević-Ramoševac, Sabina Semiz — 2013
• A phase I pharmacokinetic study of bexarotene with paclitaxel and carboplatin in patients with advanced non-small cell lung cancer (NSCLC)Jordi Rodón, Charlotte Jacobs, Quincy S. Chu — 2012
• Pitavastatin: a New 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor for the treatment of hyperlipidemiaWilliam L. Baker, Rupangi Datta — 2011
• Chemical inhibitors of cytochrome P450 isoforms in human liver microsomes: a re-evaluation of P450 isoform selectivityS. Cyrus Khojasteh, Saileta Prabhu, Jane R. Kenny — 2011
• Pitavastatin: efficacy and safety profiles of a novel synthetic HMG-CoA reductase inhibitor.Kouji Kajinami, Noboru Takekoshi, Yasushi Saito — 2006
• Prediction of the metabolic interaction of nateglinide with other drugs based on in vitro studies.Toshiyuki Takanohashi, Tomonori Koizumi, Ryuichi Mihara — 2007
• Statin/fibrate combination in patients with metabolic syndrome or diabetes: evaluating the risks of pharmacokinetic drug interactionsMichael H Davidson — 2006
• GLUCURONIDATION CONVERTS GEMFIBROZIL TO A POTENT, METABOLISM-DEPENDENT INHIBITOR OF CYP2C8: IMPLICATIONS FOR DRUG-DRUG INTERACTIONSBrian W. Ogilvie, Donglu Zhang, Wenying Li — 2006
• Inhibition of Hepatic Organic Anion-Transporting Polypeptide by RNA Interference in Sandwich-Cultured Human Hepatocytes: An In Vitro Model to Assess Transporter-Mediated Drug-Drug InteractionsMingxiang Liao, Arek Raczynski, Michael Chen — 2010
• Mechanism-based inhibition of CYP2C8 by gemfibrozil in humans : characterisation of time and dose relationshipsJohanna Honkalammi — 2011
• Role of Cytochrome P450 2C8 in Drug Metabolism and InteractionsJanne T. Backman, Anne M. Filppula, Mikko Niemi — 2016
• Metabolic Stability and Uptake by Human Hepatocytes of Pitavastatin, a New Inhibitor of HMG-CoA ReductaseHideki Fujino, Daisuke Nakai, Rie Nakagomi — 2004
• Evaluation of Proposed In Vivo Probe Substrates and Inhibitors for Phenotyping Transporter Activity in HumansJeremiah D. Momper, Shirley M. Tsunoda, D. Joseph — 2016
• Role of CYP2C8 in the metabolism of montelukast and imatinib : Studies in vitro, in silico and in humansAnne M. Filppula — 2014
• Quantitative Analysis of Complex Drug-Drug Interactions Between Repaglinide and Cyclosporin A/Gemfibrozil Using Physiologically Based Pharmacokinetic Models With In Vitro Transporter/Enzyme Inhibition Data.Soojin Kim, Kota Toshimoto, Yoshiaki Yao — 2017
• Pitavastatin: focus on safety and drug interactionsЛ. О. Минушкина, D. A. Zateyshchikov — 2021
• Revisiting CYP2C9-Mediated drug-drug Interactions: A ReviewNurliana Abd Mutalib, Mohd Amirul Ariffin Mohd Rafi, Normala Abd Latip — 2021
• Role of CYP2C8 in the metabolism of montelukast and imatinib : Studies in vitro, in silico and in humansAnne M. Filppula — 2014

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• [Gemfibrozil reduces elevated lipoprotein (a) levels in hypercholesterolemic patients].José Antônio Franchini Ramires, Andrei C. Spósito, Antônio de Pádua Mansur — 1997
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• Gemfibrozil as a Lipid Lowering Compound in Hyperlipoproteinæmia. A Placebo-controlled Cross-over TrialB. Vessby, Hans Lithell, Jonas Boberg — 1976
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