Aldosterone in congestive heart failure.
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Summary
A review article gives an in-depth update on the mechanisms of action of aldosterone and their implications for therapy and underscores the value of a Aldosterone-receptor antagonists, such as spironolactone, in the treatment of chronic heart failure.
- Type
- review
- Published
- 2001-12-06
- Cited by
- 341
- References
- 81
- OpenAlex
- https://openalex.org/W2027163029
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:32108583
Keywords
Spironolactone, Aldosterone, Heart failure, Medicine, Mineralocorticoid receptor
References
- Aldosterone-induced inflammation in the rat heart : role of oxidative stress.
- Spironolactone increases nitric oxide bioactivity, improves endothelial vasodilator dysfunction, and suppresses vascular angiotensin I/angiotensin II conversion in patients with chronic heart failure.
- Regulation of aldosterone synthase in human vascular endothelial cells by angiotensin II and adrenocorticotropin.
- Serum markers of collagen type I metabolism in spontaneously hypertensive rats: relation to myocardial fibrosis.
- Structural and functional study of the rat distal nephron: effects of potassium adaptation and depletion.
- Pathological Hypertrophy and Cardiac Interstitium: Fibrosis and Renin‐Angiotensin‐Aldosterone System
- Sodium and water balance in chronic congestive heart failure.
- Regulation of glomerular filtration rate in chronic congestive heart failure patients.
- CARDIAC OUTPUT, BLOOD AND INTERSTITIAL FLUID VOLUMES, TOTAL CIRCULATING SERUM PROTEIN, AND KIDNEY FUNCTION DURING CARDIAC FAILURE AND AFTER IMPROVEMENT.
- Extracellular matrix remodeling in heart failure: a role for de novo angiotensin II generation.
- Angiotensin-independent mechanism for aldosterone synthesis during chronic extracellular fluid volume depletion.
- Response of normal subjects to large amounts of aldosterone.
- Isoform-specific modulation of Na+, K+-ATPase alpha-subunit gene expression in hypertension.
- Spontaneous hypopotassemia, hypomagnesemia, alkalosis and tetany due to hypersecretion of corticosterone-like mineralocorticoid.
- Role of aldosterone in the remnant kidney model in the rat.
- Increased serum concentrations of procollagen peptides in essential hypertension. Relation to cardiac alterations.
- MODE OF ACTION AND CLINICAL USEFULNESS OF ALDOSTERONE ANTAGONISTS *
- Observations on the sodium-retaining corticoid (aldosterone) in the urine of children and adults in relation to sodium balance and edema.
- Hormonal changes and catabolic/anabolic imbalance in chronic heart failure and their importance for cardiac cachexia.
- Myocardial Production of Aldosterone and Corticosterone in the Rat
Cited by
- Aldosterone-receptor antagonism and end-stage renal disease
- Narrative Review: Pharmacotherapy for Chronic Heart Failure: Evidence from Recent Clinical Trials
- Cardiorenal Syndrome: Pathophysiology and Treatment
- The Role of Renin Angiotensin Aldosterone System Genes in Diabetic Nephropathy.
- Myocardial pathology induced by aldosterone is dependent on non-canonical activities of G protein-coupled receptor kinases
- Ischemic heart disease in the older patient
- Role of the Renin-Angiotensin-Aldosterone System in Diastolic Heart Failure
- Current understanding of heart failure with preserved ejection fraction
- Corticosteroid hormone action in the cardiovascular system
- Congestive heart failure: guidelines for the primary care physician.
- Role of diminished renal function in cardiovascular mortality: marker or pathogenetic factor?
- Serum soluble ST2: a potential novel mediator in left ventricular and infarct remodeling after acute myocardial infarction.
- Guanylin peptides in heart failure
- Aldosterone-induced cardiomyocyte growth, and fibroblast migration and proliferation are mediated by TRAF3IP2.
- Pharmacological treatment of aldosterone excess.
- Association of AGTR1 gene A1166C polymorphism with the risk of heart failure: a meta-analysis.
- Which ARB drug is better for heart failure therapy? Aldosterone suppression holds the answer
- Treatment of heart failure with preserved ejection fraction. An unresolved problem.
- Aldosteronblockade bei gering symptomatischer Herzinsuffizienz
- Beneficial neurohormonal profile of spironolactone in severe congestive heart failure: results from the RALES neurohormonal substudy.
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