The stress-activated protein kinase subfamily of c-Jun kinases
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Summary
The kinase p54s are the principal c-Jun N-terminal kinases activated by cellular stress and tumour necrosis factor (TNF)-α, hence they are designated stress-activated protein kinases, or SAPKs.
- Type
- article
- Published
- 1994-05-12
- Cited by
- 2,734
- References
- 27
- OpenAlex
- https://openalex.org/W2026951979
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4356644
Keywords
Kinase, Phosphorylation, Cell biology, Mitogen-activated protein kinase, Biology
References
- Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase
- pp54 microtubule-associated protein 2 kinase. A novel serine/threonine protein kinase regulated by phosphorylation and stimulated by poly-L-lysine.
- MAP kinase activator from insulin‐stimulated skeletal muscle is a protein threonine/tyrosine kinase.
- Identification of the regulatory phosphorylation sites in pp42/mitogen‐activated protein kinase (MAP kinase).
- Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation. Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase.
- An array of insulin-activated, proline-directed serine/threonine protein kinases phosphorylate the p70 S6 kinase.
- The sphingomyelin cycle and the second messenger function of ceramide.
- Phosphorylation of c-jun mediated by MAP kinases
- ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF.
- JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain.
- Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain
- Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases
- The mammalian ultraviolet response is triggered by activation of Src tyrosine kinases.
- Phorbol esters stimulate the phosphorylation of c-Jun but not v-Jun: regulation by the N-terminal delta domain.
- The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.
- Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II
- A putative protein kinase overcomes pheromone-induced arrest of cell cycling in S. cerevisiae.
- Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73
- Raf-1 activates MAP kinase-kinase
- Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.
Cited by
- Molecular mechanisms of bromate-induced renal toxicity
- Phosphorylation state of the RNA polymerase II C-terminal domain (CTD) in heat-shocked cells. Possible involvement of the stress-activated mitogen-activated protein (MAP) kinases.
- The cellular response to unfolded proteins: intercompartmental signaling.
- CD28 signal transduction pathways. A comparison of B7-1 and B7-2 regulation of the map kinases: ERK2 and Jun kinases.
- Role for p38 Mitogen-activated Protein Kinase in Platelet Aggregation Caused by Collagen or a Thromboxane Analogue (*)
- Tumor Necrosis Factor α-Induced E-selectin Expression Is Activated by the Nuclear Factor-κB and c-JUN N-terminal Kinase/p38 Mitogen-activated Protein Kinase Pathways*
- Phosphorylation of Protein-tyrosine Phosphatase PTP-1B on Identical Sites Suggests Activation of a Common Signaling Pathway during Mitosis and Stress Response in Mammalian Cells*
- Mitogen-activated Protein Kinase Phosphatases Inactivate Stress-activated Protein Kinase Pathways in Vivo*
- Discordant Activation of Stress-activated Protein Kinases or c-Jun NH2-terminal Protein Kinases in Tissues of Heat-stressed Mice*
- Lysophosphatidylcholine Stimulates Activator Protein 1 and the c-Jun N-terminal Kinase Activity*
- Activation of Stress-activated Protein Kinase/c-Jun N-terminal Kinase, but Not NF-κB, by the Tumor Necrosis Factor (TNF) Receptor 1 through a TNF Receptor-associated Factor 2- and Germinal Center Kinase Related-dependent Pathway*
- Activation of p42mapk in human umbilical vein endothelial cells by interleukin-1α and tumor necrosis factor-α.
- Signal transduction through MAP kinase cascades.
- Opposing Effects of Jun Kinase and p38 Mitogen-Activated Protein Kinases on Cardiomyocyte Hypertrophy
- Regulation of mitogen-activated protein kinase cascades in the heart.
- Coordinate Activation of Activator Protein 1 and Inflammatory Cytokines in Response to Neisseria gonorrhoeae Epithelial Cell Contact Involves Stress Response Kinases
- Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells
- Murine p38-δ Mitogen-activated Protein Kinase, a Developmentally Regulated Protein Kinase That Is Activated by Stress and Proinflammatory Cytokines*
- Distinct localization of SAPK isoforms in neurons of adult mouse brain implies multiple signaling modes of SAPK pathway.
- Heightened induction of c-jun mRNA by PMA, EGF and IL-1 in ataxia telangiectasia lymphoblasts.
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