Electrophysiological variability in the SH-SY5Y cellular line.
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Summary
The results confirm earlier findings that this cell line is not constituted of an uniform population of cells and conclude that these cells have diverse regulatory patterns of membrane conductance, probably due to both the expression as well as a non precise regulation of the membrane density of the different channels.
- Type
- article
- Published
- 2014-01-01
- Cited by
- 29
- References
- 11
- Access
- Open access
- OpenAlex
- https://openalex.org/W2026638115
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:22916480
Keywords
Electrophysiology, Patch clamp, SH-SY5Y, Voltage clamp, Membrane potential
References
- SH-SY5Y human neuroblastoma cell line: in vitro cell model of dopaminergic neurons in Parkinson's disease.
- Elevation of cytosolic calcium by cholinoceptor agonists in SH‐SY5Y human neuroblastoma cells: estimation of the contribution of voltage‐dependent currents
- Sequential Treatment of SH‐SY5Y Cells with Retinoic Acid and Brain‐Derived Neurotrophic Factor Gives Rise to Fully Differentiated, Neurotrophic Factor‐Dependent, Human Neuron‐Like Cells
- The retinoic acid and brain-derived neurotrophic factor differentiated SH-SY5Y cell line as a model for Alzheimer's disease-like tau phosphorylation.
- Functional changes in potassium conductances of the human neuroblastoma cell line SH-SY5Y during in vitro differentiation.
- High expression of large-conductance Ca2+-activated K+ channel in the CD133+ subpopulation of SH-SY5Y neuroblastoma cells.
- Nicotinic modulation of gene expression in SH-SY5Y neuroblastoma cells.
- An In Vitro Model for Neuroscience: Differentiation of SH-SY5Y Cells into Cells with Morphological and Biochemical Characteristics of Mature Neurons
- SH-SY5Y human neuroblastoma cell line： in vitro cell model of dopaminergic neurons in Parkinson＇s disease
Cited by
- Bio-hybrid interfaces to study neuromorphic functionalities: New multidisciplinary evidences of cell viability on poly(anyline) (PANI), a semiconductor polymer with memristive properties.
- Paracrine Maturation and Migration of SH-SY5Y Cells by Dental Pulp Stem Cells
- Treating TB human neuroectodermal cell line with retinoic acid induces the appearance of neuron-like voltage-gated ionic currents.
- Accounting for variability in ion current recordings using a mathematical model of artefacts in voltage-clamp experiments
- From cell lines to pluripotent Stem Cells for Modelling Parkinson's Disease.
- Substrate stiffness effects on SH-SY5Y: The dichotomy of morphology and neuronal behavior.
- Electrophysiological Profile Remodeling via Selective Suppression of Voltage-Gated Currents by CLN1/PPT1 Overexpression in Human Neuronal-Like Cells
- Single-cell brain atlas of Parkinson's disease mouse model.
- Monoallelic and bi-allelic variants in NCDN cause neurodevelopmental delay, intellectual disability, and epilepsy
- The Effects of Serum Removal on Gene Expression and Morphological Plasticity Markers in Differentiated SH-SY5Y Cells
- Ischemic Stroke and Sleep: The Linking Genetic Factors
- Studies on Regulation of Global Protein Profile and Cellular Bioenergetics of Differentiating SH-SY5Y Cells
- TRPV1 channels in nitric oxide-mediated signalling: Insight on excitatory transmission in rat CA1 pyramidal neurons.
- Effects of Novel Photosynthetic Inhibitor [CuL2]Br2 Complex on Photosystem II Activity in Spinach
- Guanosine modulates K+ membrane currents in SH-SY5Y cells: involvement of adenosine receptors
- A Polymer Bio–Photoelectrolytic Platform for Electrical Signal Measurement and for Light Modulation of Ion Fluxes and Proliferation in a Neuroblastoma Cell Line
- Numerical investigation of force and deflection of nanoneedle penetration into cell using finite element approach: Parameter study and experimental validation of results
- Antidepressants escitalopram and venlafaxine up-regulate BDNF promoter IV but down-regulate neurite outgrowth in differentiating SH-SY5Y neurons.
- Lipid levels correlate with neuronal and dopaminergic markers during the differentiation of SH-SY5Y cells
- Recent Insights into the Etiopathogenesis of Diabetic Retinopathy and Its Management
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