Shedding light onto live molecular targets

Summary

Optical sensing of specific molecular targets and pathways deep inside living mice has become possible as a result of a number of advances, which will provide new tools making it possible to understand more fully the functioning of protein networks, diagnose disease earlier and speed along drug discovery.

Keywords

Biocompatible material, Drug discovery, Nanotechnology, Computational biology, Computer science

References

GFP‐like chromoproteins as a source of far‐red fluorescent proteinsNadya G. Gurskaya, Arkady F. Fradkov, Alexey V. Terskikh — 2001
Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligandsAndreas Becker, Carsten Hessenius, Kai Licha — 2001
Revealing the spatiotemporal patterns of bacterial infectious diseases using bioluminescent pathogens and whole body imaging.Stacy M. Burns, Danny Joh, Kevin P. Francis — 2001
Fluorescent proteins from nonbioluminescent Anthozoa speciesMikhail V. Matz, Arkady F. Fradkov, Yulii A. Labas — 1999
Optical imaging of cancer metastasis to bone marrow: a mouse model of minimal residual disease.Antoinette Wetterwald, Gabri van der Pluijm, Ivo Que — 2002
In vivo molecular target assessment of matrix metalloproteinase inhibitionChristoph Bremer, Ching‐Hsuan Tung, Ralph Weissleder — 2001
In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopyEdward B. Brown, R. B. Campbell, Yoshikazu Tsuzuki — 2001
In Vivo Imaging of NF-κB Activity1Harald Carlsen, Jan Ø. Moskaug, Sigurd H. Fromm — 2002
In vivo imaging of proteolytic enzyme activity using a novel molecular reporter.Ching‐Hsuan Tung, Umar Mahmood, Sebastian Bredow — 2000
Rapid in vivo functional analysis of transgenes in mice using whole body imaging of luciferase expressionWeisheng Zhang, Jian Q. Feng, Stephen E. Harris — 2001
Hydrophilic Cyanine Dyes as Contrast Agents for Near-infrared Tumor Imaging: Synthesis, Photophysical Properties and Spectroscopic In vivo Characterization¶Kai Licha, Björn Riefke, Vasilis Ntziachristos — 2000
In vivo characterization of cyanine dyes as contrast agents for near-infrared imagingBjoern Riefke, Kai Licha, Wolfhard Semmler — 1996
Fluorescently detectable magnetic resonance imaging agents.Martina M. Hüber, Andrea B. Staubli, Karen Kustedjo — 1998
Visualizing Gene Expression in Living Mammals Using a Bioluminescent ReporterChristopher H. Contag, Stanley D. Spilman, Pamela R. Contag — 1997
Adverse reactions due to indocyanine green.M. Hope–Ross, L. A. Yannuzzi, E. S. Gragoudas — 1994
Non-invasive optical spectroscopy and imaging of human brain function.Arno Villringer, Britton Chance — 1997
Cellular activation of the self-quenched fluorescent reporter probe in tumor microenvironment.Alexei Bogdanov, Charles P. Lin, Maria A. Simonova — 2002
In vivo identification of colonic dysplasia using fluorescence endoscopic imaging.Thomas D. Wang, James M. Crawford, Michael S. Feld — 1999
Visualizing gene expression by whole-body fluorescence imaging.Meng Yang, Eugene Baranov, A. R. Moossa — 2000
Deep subsurface imaging in tissues using spectral and polarization filtering.Stavros G. Demos, Harry B. Radousky, R. R. Alfano — 2000

Cited by

Monte Carlo method for bioluminescence tomography.Deepak Kumar, W X Cong, Ge Wang — 2007
Functional imaging in small animals using X-ray computed Tomography -study of physiologic measurement reproducibility王庆民 — 2005
Dual-modality in vivo monitoring of subventricular zone stem cell migration and metabolism.Gonçal López-Pampló Rius — 2007
Investigating Pharmacology In Vivo Using Magnetic Resonance and Optical ImagingJorge Rodríguez Padrón — 2008
Chapter 5: Imaging in depth: controversies and opportunities.Simon van den Berg — 2008
Sensors as tools for quantitation, nanotoxicity and nanomonitoring assessment of engineered nanomaterials.Omowunmi A. Sadik, A. Zhou, Samuel N. Kikandi — 2009
Development of a Universal Anti–Polyethylene Glycol Reporter Gene for Noninvasive Imaging of PEGylated ProbesVictoria Oliveros — 2010
Hybrid x-ray/optical luminescence imaging: characterization of experimental conditions.José Carlos Fariñas García — 2010
In vivo fluorescence lifetime optical projection tomography省三吉田 — 2011
Establishment and Characterization of a Transgenic Mouse Model for In Vivo Imaging of Bmp4 Expression in the PancreasJohn Peterson — 2011
In situ labeling and imaging of cellular protein via a bi-functional anticancer aptamer and its fluorescent ligand.Manuel Rolandi Sánchez-Solís — 2012
Optimizing the synthesis of CdS/ZnS core/shell semiconductor nanocrystals for bioimaging applications君江黒川 — 2014
Dual PET and Near-Infrared Fluorescence Imaging Probes as Tools for Imaging in OncologyHelen L. Wardeberg — 2016
Mathematical method in optical molecular imagingChengcai Leng, Jie Tian — 2015
Liposome-supported enzymatic peritoneal dialysis.石田裕敏 — 2017
X-ray fluorescence tomographic system design and image reconstructionWenxiang Cong, Haiou Shen, Guohua Cao — 2013
Recent advances in all-protein chromophore technology.Mark Prescott, Jion M. Battad, Pascal G. Wilmann — 2006
Hyperspectral and multispectral optical bioluminescence and fluorescence tomography in small animal imagingAbhijit J. Chaudhari — 2007
Magnetic resonance and fluorescence based molecular imaging technologies.David E. Sosnovik, Ralph Weissleder — 2005
Combined in vivo molecular and anatomic imaging for detection of ovarian carcinoma-associated protease activity and integrin expression in mice.Harvey H. Hensley, Navid A. Roder, Shane W. O’Brien — 2012

Related papers

[Research advances on the application of biocompatible materials in treating diabetic wounds].Kuan‐Ting Liu, Dan Hu — 2021
Methods for obtaining and processing biocompatible medical materialsMikhail Ivanov, Elena Poddubskaya, Н. В. Учеваткина — 2019
CHEMICAL COMPOSITIONS AND ANALYSIS OF BIOCOMPATIBLE MATERIAL(S), TECHNOLOGICAL ADVANCEMENT AND STANCEMedtronic, California, USA, Ajay S. Panwar, Jasdeep Shangari — 2022
Biocompatible all overMartin J Davies — 2001
Scientific Approaches to the Creation of Biocompatible Implant MaterialsAlexander Markov, Georgy S. Soloviev, Ivan Petrov — 2021
Using model-system genetics for drug-based target discovery.David J. Matthews, Jenny Kopczynski — 2001
Structural biology and drug discovery.Miles Congreve, Christopher W. Murray, Tom L. Blundell — 2005
The use of constitutively active GPCRs in drug discovery and functional genomicsDerek Chalmers, Dominic P. Behan — 2002
The modular approach to ligand discovery.Charles Karan, John A. Tallarico — 2004
Functional cell-based uHTS in chemical genomic drug discovery.Glenn Croston — 2002