PROVEAN web server: a tool to predict the functional effect of amino acid substitutions and indels
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Summary
A web server to predict the functional effect of single or multiple amino acid substitutions, insertions and deletions using the prediction tool PROVEAN, which provides rapid analysis of protein variants from any organisms, and also supports high-throughput analysis for human and mouse variants at both the genomic and protein levels.
- Type
- article
- Published
- 2015-08-15
- Cited by
- 2,372
- References
- 8
- Access
- Open access
- OpenAlex
- https://openalex.org/W2024405748
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:28166086
Keywords
Web server, Biology, Login, Indel, Computational biology
References
- Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm
- A fast computation of pairwise sequence alignment scores between a protein and a set of single-locus variants of another protein
- Needles in stacks of needles: finding disease-causal variants in a wealth of genomic data
- A method and server for predicting damaging missense mutations
- Predicting the Functional Effect of Amino Acid Substitutions and Indels
- Predicting the effects of amino acid substitutions on protein function.
- Predicting deleterious amino acid substitutions.
- PSIC: profile extraction from sequence alignments with position-specific counts of independent observations.
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- Exome Sequencing and the Management of Neurometabolic Disorders
- The role of small in-frame insertions/deletions in inherited eye disorders and how structural modelling can help estimate their pathogenicity
- Multimodal characterization of a novel mutation causing vitamin B6-responsive gyrate atrophy
- A de novo KCNA1 Mutation in a Patient with Tetany and Hypomagnesemia
- The common VWF single nucleotide variants c.2365A>G and c.2385T>C modify VWF biosynthesis and clearance.
- Salivary gland anlage tumor: molecular profiling sheds light on a morphologic question.
- Sequence variation of necdin gene in Bovidae
- Molecular characterization of Bu-1 and TLR2 gene in Haringhata Black chicken.
- Whole-exome sequencing in familial type 2 diabetes identifies an atypical missense variant in the RyR2 gene
- Exon array analysis reveals genetic heterogeneity in atypical femoral fractures. A pilot study
- Validation of Next-Generation Sequencing of Entire Mitochondrial Genomes and the Diversity of Mitochondrial DNA Mutations in Oral Squamous Cell Carcinoma
- Pulmonary Arterial Hypertension: A Current Perspective on Established and Emerging Molecular Genetic Defects
- Genomic landscapes of breast fibroepithelial tumors
- Temporal order of RNase IIIb and loss-of-function mutations during development determines phenotype in pleuropulmonary blastoma / DICER1 syndrome: a unique variant of the two-hit tumor suppression model
- The genetic architecture of NAFLD among inbred strains of mice
- Integrated genomics approach to identify biologically relevant alterations in fewer samples
- Systematic evaluation of underlying defects in DNA repair as an approach to case-only assessment of familial prostate cancer
- Homozygous missense mutation in the LMAN2L gene segregates with intellectual disability in a large consanguineous Pakistani family
- Integration of Structural Dynamics and Molecular Evolution via Protein Interaction Networks: A New Era in Genomic Medicine
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