Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function.
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Summary
Findings raise the possibility that Grb-IR is a SH2-domain-containing protein that directly complexes with the IR and serves to inhibit signaling or redirect the IR signaling pathway.
- Type
- article
- Published
- 1995-10-24
- Cited by
- 166
- References
- 3
- Access
- Open access
- OpenAlex
- https://openalex.org/W2024153969
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:19140557
Keywords
Insulin receptor, IRS1, GRB10, Biology, SH2 domain
References
- Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location
- PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase
- Erratum: Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene (Nature (1994) 372 (186-190))
Cited by
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- A role for caveolin-3 in the pathogenesis of the mdx mouse
- Investigating the role of the imprinted Grb10 gene in the regulation of maternal nutrient transfer.
- Duplication of 7p11.2-p13, including GRB10, in Silver-Russell syndrome.
- Effect of Nedd4 haploinsufficiency on insulin sensitivity, adiposity and neuronal behaviors
- Selective and Specific Activation of Rab5 during Endocytosis of Receptor Tyrosine Kinases
- Binding of SH2 containing proteins to the insulin receptor: A new way for modulating insulin signalling
- GIGYF2 is present in endosomal compartments in the mammalian brains and enhances IGF‐1‐induced ERK1/2 activation
- Empreinte génomique parentale et petits ARN non-codants
- The Genetics of the Silver-Russell Syndrome
- Grb10: more than a simple adaptor protein.
- Brain-Derived Neurotrophic Factor (BDNF) Modulation of Kv1.3 in the Olfactory Bulb
- On asymptotic properties of some complex Lorenz-like systems
- Inhibition of Rab5 Activation During Insulin Receptor-Mediated Endocytosis
- Grb10, a Positive, Stimulatory Signaling Adapter in Platelet-Derived Growth Factor BB-, Insulin-Like Growth Factor I-, and Insulin-Mediated Mitogenesis
- Placental expression of the insulin receptor binding protein GRB10: Relation to human fetoplacental growth and fetal gender.
- Functional characterization of GYF-domain containing proteins
- Grb10 Deletion Enhances Muscle Cell Proliferation, Differentiation and GLUT4 Plasma Membrane Translocation
- Interaction between the Grb10 SH2 Domain and the Insulin Receptor Carboxyl Terminus (*)
- Rin1 regulates insulin receptor signal transduction pathways.
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