A yeast gene important for protein assembly into the endoplasmic reticulum and the nucleus has homology to DnaJ, an Escherichia coli heat shock protein

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Summary

Conditional- lethal mutants (npl, for nuclear protein localization) that missorted NLS-cytochrome c1 to the mitochondria, allowing growth on glycerol are isolated and may act at a very early common step in localization of proteins to the nucleus and the ER.

Type
article
Published
1989-12-01
Cited by
272
References
45
Access
Open access

Keywords

Biology, Endoplasmic reticulum, Nuclear localization sequence, Cell biology, Inner membrane

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