Evidence that human cardiac myocytes divide after myocardial infarction.
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Summary
The results challenge the dogma that the adult heart is a postmitotic organ and indicate that the regeneration of myocytes may be a critical component of the increase in muscle mass of the myocardium.
- Type
- article
- Published
- 2001-06-07
- Cited by
- 690
- References
- 44
- OpenAlex
- https://openalex.org/W2022185139
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24887335
Keywords
Cytokinesis, Mitosis, Myocyte, Medicine, Cardiology
References
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- TAK1 is activated in the myocardium after pressure overload and is sufficient to provoke heart failure in transgenic mice
- Bone marrow cells regenerate infarcted myocardium
- The Ki‐67 protein: From the known and the unknown
- The location of pKi67 in the outer dense fibrillary compartment of the nucleolus points to a role in ribosome biogenesis during the cell division cycle
- The biochemical characterization of the DNA binding activity of pKi67
- Male Pseudohermaphroditism Related to Complications at Conception, in Early Pregnancy or in Prenatal Growth
- Myocyte proliferation in end-stage cardiac failure in humans.
- Hypospadias is related to birth weight in discordant monozygotic twins.
- Heart failure from the point of view of quantitative anatomy.
- Adenoviral delivery of E2F-1 directs cell cycle reentry and p53-independent apoptosis in postmitotic adult myocardium in vivo.
- Immunohistochemical markers of cellular proliferation: achievements, problems and prospects
- The cellular basis of pacing-induced dilated cardiomyopathy. Myocyte cell loss and myocyte cellular reactive hypertrophy.
- Regulation of cytokinesis
- Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication.
- Structural basis of end-stage failure in ischemic cardiomyopathy in humans.
Cited by
- bcl-2 overexpression promotes myocyte proliferation
- Involvement of cyclin D activity in left ventricle hypertrophy in vivo and in vitro.
- Cardiac myocyte remodeling in hypertrophy and progression to failure.
- Cellular cardiomyoplasty--cardiomyocytes, skeletal myoblasts, or stem cells for regenerating myocardium and treatment of heart failure?
- Autologous Stem Cells for Functional Myocardial Repair
- Endogenous bone-marrow-derived stem cells contribute only a small proportion of regenerated myocardium in the acute infarction model.
- Cardiac contractility after transplantation of autologous mononuclear bone marrow cells in patients with myocardial infarction
- Ventricular Myocardial Fat: CT Findings and Clinical Correlates
- The cardiomyocyte cell cycle in hypertrophy, tissue homeostasis, and regeneration.
- Control of autocrine and paracrine myocardial signals: an emerging therapeutic strategy in heart failure
- Stem cell therapy in cardiovascular disorders.
- Role of stem cells in cardiovascular biology
- Cell therapy, 3D culture systems and tissue engineering for cardiac regeneration.
- Myocardial ischemic injury and protection.
- Cell lineages, growth and repair of the mouse heart.
- Concetti base di ingegneria tissutale nelle valvole cardiache e valutazione di strutture cardiovascolari umane adulte come potenziale fonte cellulare
- Embryonic and adult stem cell-derived cardiomyocytes: lessons from in vitro models.
- Strategies Using Cell Therapy to Induce Cardiomyocyte Regeneration in Adults with Heart Disease
- Development of approaches to improve the regenerative potential of muscle stem cells
- Desenvolvimento de protocolos pré-clínicos de terapia celular em roedores para o tratamento da cardiopatia isquêmica
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