A critical analysis of the role of growth hormone and IGF-1 in aging and lifespan.
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Summary
This work critiques the current mammalian models of GH/IGF-1 deficiency and discusses the actions of GH or IGF-1 on biological aging and lifespan.
- Type
- review
- Published
- 2002-06-01
- Cited by
- 174
- References
- 66
- OpenAlex
- https://openalex.org/W2022075548
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:31553467
Keywords
Biology, Signal transduction, Caenorhabditis elegans, Insulin-like growth factor, Growth factor
References
- Antibody to type I insulinlike growth factor receptor inhibits growth of Wilms' tumor in culture and in athymic mice.
- Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling
- The role of the insulin-like growth factor system in human cancer.
- Partial characterization of insulin-like growth factor I in primary human lung cancers using immunohistochemical and receptor autoradiographic techniques.
- Effects of insulin-like growth factor receptor inhibition on human melanomas in culture and in athymic mice.
- Human osteosarcoma cell lines are dependent on insulin-like growth factor I for in vitro growth.
- Growth inhibition of human breast cancer cells in vitro with an antibody against the type I somatomedin receptor.
- Inherited ateliotic dwarfism in mice. Characteristics of the mutation, little, on chromosome 6.
- Reduced Levels of Thyroid Hormones, Insulin, and Glucose, and Lower Body Core Temperature in the Growth Hormone Receptor/Binding Protein Knockout Mouse
- The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake.
- Evolution of senescence: late survival sacrificed for reproduction.
- Growth hormone induces somatostatin and insulin-like growth factor I gene expression in the cerebral hemispheres of aging rats.
- Growth hormone treatment increases transmural colonic growth in GH-deficient dwarf rats.
- DWARF, A NEW MENDELIAN RECESSIVE CHARACTER OF THE HOUSE MOUSE.
- Does growth hormone prevent or accelerate aging?
- A test of evolutionary theories of senescence
- Human osteosarcoma (U‐2 OS) cells express both insulin‐like growth factor‐I (IGF‐I) receptors and insulin‐like growth factor‐II/mannose‐6‐phosphate (IGF‐II/M6P) receptors and synthesize IGF‐II: Autocrine growth stimulation by IGF‐II via the IGF‐I receptor
- Longevity: Extending the lifespan of long-lived mice
- Processing of insulin-like growth factor-II (IGF-II) by human breast cancer cells.
- Pituitary-Induced Alterations in Gastrin Levels and Gastrointestinal Growth in Normal and Genetically Dwarf Mice
Cited by
- Mutations in Chemosensory Cilia Cause Resistance to Paraquat in Nematode Caenorhabditis elegans*
- Do large dogs die young?
- Basic physiology of the growth hormone/insulin-like growth factor axis.
- The biology of death in Caenorhabditis elegans
- Hormonal interventions of aging and longevity.
- The Growth Hormone/Insulin-Like Growth Factor Axis During Development
- Uncoupling proteins : regulation by IGF-1 and neuroprotection during hyperglycemia in vitro.
- Testing the hyperfunction theory of ageing in Caenorhabditis elegans
- Insulin therapy in diabetes and cancer risk: Current understanding and implications for future study
- The adipokine leptin mediates muscle- and liver-derived IGF-1 in aged mice
- Signalling pathways for insulin‐like growth factor type 1‐mediated expression of uncoupling protein 3
- Age‐related changes in the metabolism and body composition of three dog breeds and their relationship to life expectancy
- Age‐dependent impairment of number and angiogenic potential of adipose tissue‐derived progenitor cells
- Genome Instability in Development and Aging: Insights from Nucleotide Excision Repair in Humans, Mice, and Worms
- Aging genetics and aging.
- Growth hormone in the aging male
- Novel mutations of the growth hormone 1 (GH1) gene disclosed by modulation of the clinical selection criteria for individuals with short stature
- Pituitary removal in adult mice increases life span.
- Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span.
- Long-term deficiency of circulating and hippocampal insulin-like growth factor I induces depressive behavior in adult mice: A potential model of geriatric depression
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