T-helper type 2-driven inflammation defines major subphenotypes of asthma.
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Summary
Asthma can be divided into at least two distinct molecular phenotypes defined by degree of Th2 inflammation, and Th2 cytokines are likely to be a relevant therapeutic target in only a subset of patients with asthma.
- Type
- article
- Published
- 2009-09-01
- Cited by
- 1,742
- References
- 40
- Access
- Open access
- OpenAlex
- https://openalex.org/W2021701428
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10492890
Keywords
Medicine, Asthma, Immunology, Inflammation, Eosinophilia
References
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Cited by
- Natural products triggering biological targets--a review of the anti-inflammatory phytochemicals targeting the arachidonic acid pathway in allergy asthma and rheumatoid arthritis.
- Can bronchial asthma be classified based on the immunological status?
- Gene-environment interaction in chronic disease: a European Science Foundation Forward Look.
- Middle Ear Response of Muc5ac and Muc5b Mucins to Nontypeable Haemophilus influenzae.
- Is the Road to Precision Medicine in Chronic Lung Disease Paved with Degraded Chitin?
- Inundation of asthma target research: Untangling asthma riddles.
- Asthma attacks: should we nail our colours to the mast (cell)?
- Severe asthma in humans and mouse model suggests a CXCL10 signature underlies corticosteroid-resistant Th1 bias.
- Adipokines in inflammatory lung diseases
- Accuracy of a New Algorithm to Identify Asthma-COPD Overlap (ACO) Patients in a Cohort of Patients with Chronic Obstructive Airway Disease.
- Squamous Cell Carcinoma Antigen 2 (SCCA2, SERPINB4): An Emerging Biomarker for Skin Inflammatory Diseases
- Updates on T helper type 17 immunity in respiratory disease
- A Novel Insight on Endotyping Heterogeneous Severe Asthma Based on Endoplasmic Reticulum Stress: Beyond the “Type 2/Non-Type 2 Dichotomy”
- Targeting Chronic Obstructive Pulmonary Disease Phenotypes, Endotypes, and Biomarkers.
- IL CONDENSATO DELL'ARIA ESPIRATA NELLO STUDIO DI PATOLOGIE RESPIRATORIE PEDIATRICHE
- IL-4/IL-13 axis as therapeutic targets in allergic rhinitis and asthma
- Pretreatment Frequency of Circulating Th17 Cells and FeNO Levels Predicted the Real-World Response after 1 Year of Benralizumab Treatment in Patients with Severe Asthma
- Asthma bronchiale im Kindesalter
- Endotype Driven Treatment of Asthma
- Búsqueda de perfiles moleculares diferenciales entre tolerancia y sensibilización en la respuesta alérgica
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