The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme.
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Summary
The RNA moieties of ribonuclease P purified from both E. coli and B. subtilis can cleave tRNA precursor molecules in buffers containing either 60 mM Mg2+ or 10 mM MG2+ plus 1 mM spermidine, and in vitro, the RNA and protein subunits from one species can complement sub units from the other species in reconstitution experiments.
- Type
- article
- Published
- 1983-12-01
- Cited by
- 2,473
- References
- 27
- OpenAlex
- https://openalex.org/W2021333801
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:39111511
Keywords
RNA, Biology, RNase P, Biochemistry, Ribonuclease
References
- Partial purification of RNase P from Schizosaccharomyces pombe.
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- Studies and sequences of Escherichia coli 4.5 S RNA.
- Nucleotide sequence and in vitro processing of a precursor molecule to Escherichia coli 4.5 S RNA.
- Self-splicing RNA: autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena.
- The tRNA genes punctuate the reading of genetic information in human mitochondrial DNA.
- Properties of purified ribonuclease P from Escherichia coli.
- Ribonuclease P: an enzyme with an essential RNA component.
- Veal heart ribonuclease P has an essential RNA component.
- A simplified ultrasensitive silver stain for detecting proteins in polyacrylamide gels.
- Repeated sequences and open reading frames in the 3' flanking region of the gene for the RNA subunit of Escherichia coli ribonuclease P.
- An intercistronic region and ribosome-binding site in bacterial messenger RNA.
- Recognition of local nucleotide conformation in contrast to sequence by a rRNA processing endonuclease.
- Precursor molecules of Escherichia coli transfer RNAs accumulated in a temperature-sensitive mutant.
- Nucleotide sequence of the gene encoding the RNA subunit (M1 RNA) of ribonuclease P from Escherichia coli.
- Temperature sensitive mutants of Escherichia coli for tRNA synthesis.
- The 3' terminus of 16S rRNA: secondary structure and interaction with ribosomal protein S1.
- E. coli RNAase P has a required RNA component.
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
- SnRNAs, SnRNPs, and RNA processing.
Cited by
- Molecular simulations of conformational transitions in biomolecules using a novel computational tool
- M1 RNA with large terminal deletions retains its catalytic activity.
- RNA catalysis and the origins of life.
- Probing the environment of lanthanide binding sites in yeast tRNA(Phe) by specific metal-ion-promoted cleavages.
- An expanding view of aminoglycoside-nucleic acid recognition.
- Modulation of ribonuclease P activity by calcipotriol.
- Evidence for an RNA-based catalytic mechanism in eukaryotic nuclear ribonuclease P.
- Inhibition of eukaryotic ribonuclease P activity by aminoglycosides: kinetic studies
- Archaeal RNase P has multiple protein subunits homologous to eukaryotic nuclear RNase P proteins.
- tRNA-mediated transcription antitermination in vitro: Codon–anticodon pairing independent of the ribosome
- Group II Introns: Structure and Catalytic Versatility of Large Natural Ribozymes
- Kinetic Characterization of the Coupled Folding and Binding Mechanism of Bacterial RNase P Protein: an Intrinsically Unstructured Protein
- RNase P-mediated inhibition of viral growth by exogenous administration of short oligonucleotide external guide sequence.
- Polarity effects in the lactose operon of Escherichia coli.
- Gene regulation by riboswitches
- Why Were Polysaccharides Necessary?
- Crystal structure of protein Ph1481p in complex with protein Ph1877p of archaeal RNase P from Pyrococcus horikoshii OT3: implication of dimer formation of the holoenzyme.
- Aminoglycoside Interactions with RNAs and Nucleases
- Searching genomes for ribozymes and riboswitches
- Catalytic DNAzymes: derivations and functions
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