Polymorphisms in IRF7 reduce IFNα responses of pDCs to HIV-1
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Summary
A novel association between polymorphisms in interferon regulatory factor 7 (IRF7), a master regulator of interferon-α (IFN-α), and the ability of plasmacytoid dendritic cells to produce IFN-α in response to HIV-1 is described.
- Type
- article
- Published
- 2011-03-13
- Cited by
- 37
- References
- 30
- Access
- Open access
- OpenAlex
- https://openalex.org/W1974542109
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:39493029
Keywords
Interferon regulatory factors, IRF7, Interferon, IRF1, Immunology
References
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- Comparison of atovaquone and azithromycin with trimethoprim-sulfamethoxazole for the prevention of serious bacterial infections in children with HIV infection.
Cited by
- An antiviral immune response turning against the host in pathogenic HIV infection.
- The impact of host genetic variation on infection with HIV-1
- Guidelines for the Prevention and Treatment of Opportunistic Infections among HIV-exposed and HIV-infected children: recommendations from CDC, the National Institutes of Health, the HIV Medicine Association of the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and
- Intact Type I Interferon Production and IRF7 Function in Sooty Mangabeys
- Community-Acquired Pneumonia in HIV-Infected Individuals
- HIV-1 targeting of IFN regulatory factors
- HIV-1, interferon and the interferon regulatory factor system: an interplay between induction, antiviral responses and viral evasion.
- Unmasking immune sensing of retroviruses: interplay between innate sensors and host effectors.
- Pathogenesis of HIV and the Lung
- Dendritic Cells in HIV-1 and HCV Infection: Can They Help Win the Battle?
- Type I IFN--a blunt spear in fighting HIV-1 infection.
- AIDS and HIV Infection after Thirty Years
- Type I Interferon: Understanding Its Role in HIV Pathogenesis and Therapy
- Immune activation in the course of HIV‐1 infection: Causes, phenotypes and persistence under therapy
- Immune Activation and Collateral Damage in AIDS Pathogenesis
- Global, regional, and national estimates of pneumonia burden in HIV-infected children in 2010: a meta-analysis and modelling study
- Thirty Years with HIV Infection—Nonprogression Is Still Puzzling: Lessons to Be Learned from Controllers and Long-Term Nonprogressors
- Targeting HIV-1 innate immune responses therapeutically.
- Bachelor Biomedical Sciences
- Dendritic cells at the interface of innate and adaptive immunity to HIV-1.
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