Synthetic biology: applications come of age
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Summary
The de novo engineering of genetic circuits, biological modules and synthetic pathways is beginning to address these crucial problems and is being used in related practical applications.
- Type
- review
- Published
- 2010-05-01
- Cited by
- 1,396
- References
- 135
- Access
- Open access
- OpenAlex
- https://openalex.org/W2021099440
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:2926016
Keywords
Synthetic biology, Biology, Computational biology, Systems biology
References
- Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase.
- Engineering a mevalonate pathway in Escherichia coli for production of terpenoids
- Re-engineering adenovirus regulatory pathways to enhance oncolytic specificity and efficacy
- Regulation and mode of action of the second small RNA activator of RpoS translation, RprA
- The large scale structure and dynamics of gene control circuits: an ensemble approach.
- Non–coding RNA genes and the modern RNA world
- Translation repression by antisense sequences
- A temperature-regulated replicon-based DNA expression system
- Combinatorial Synthesis of Genetic Networks
- A synthetic oscillatory network of transcriptional regulators
- Streptogramin-based gene regulation systems for mammalian cells
- Acetone-butanol fermentation revisited.
- Computational design of receptor and sensor proteins with novel functions
- The inducible Iac operator-repressor system is functional in mammalian cells
- Self-splicing RNA: autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena.
- Biofuel alternatives to ethanol: pumping the microbial well.
- A synthetic gene–metabolic oscillator
- Programmable ligand-controlled riboregulators of eukaryotic gene expression
- A genetic redox sensor for mammalian cells.
- lac repressor can regulate expression from a hybrid SV40 early promoter containing a lac operator in animal cells.
Cited by
- Developing a synthetic signal transduction system in plants.
- Using topology to tame the complex biochemistry of genetic networks
- Transferring a synthetic gene circuit from yeast to mammalian cells
- Applications of cell‐free protein synthesis in synthetic biology: Interfacing bio‐machinery with synthetic environments
- A general design strategy for protein-responsive riboswitches in mammalian cells
- Computing with Synthetic Protocells
- Synthetic biology, patenting, health and global justice
- Development of Design Rules for Reliable Antisense RNA Behavior in E. coli.
- Deciphering Combinatorial Genetics.
- Insightful directed evolution of Escherichia coli quorum sensing promoter region of the lsrACDBFG operon: a tool for synthetic biology systems and protein expression
- Developing a Synthetic Biology Toolkit for Comamonas testosteroni, an Emerging Cellular Chassis for Bioremediation.
- Programming Bacteria With Light—Sensors and Applications in Synthetic Biology
- Tunable promoters in synthetic and systems biology.
- Gene synthesis: methods and applications.
- Incorporation of bacterial quorum sensing in synthetic biology
- On the search for design principles in biological systems.
- Development of a biosensor based on linear dichroism spectroscopy
- Etude du mécanisme de recombinaison des intégrons, et leur utilisation comme générateur de combinaisons génétiques à des fins biotechnologiques
- Design and connection of robust genetic circuits.
- The ribosome binding site calculator.
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