Transcriptional activation of the promoter of human cytomegalovirus immediate early gene (CMV-IE) by the hepatitis B viral X protein (HBx) through the NF-kappaB site.
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Summary
The results suggest the possibility that the HBV infection of a cell previously infected by CMV would exert influence on the reactivation of the latent cytomegalovirus in a human to induce virus-related symptoms.
- Type
- article
- Published
- 2002-03-20
- Cited by
- 16
- References
- 46
- OpenAlex
- https://openalex.org/W2021012809
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:6652015
Keywords
HBx, Biology, Virology, Gene, Human cytomegalovirus
References
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- Cholangiopathy and tumors of the pancreas, liver, and biliary tree in boys with X-linked immunodeficiency with hyper-IgM.
- Effect of a modulator deletion on transcription of the human cytomegalovirus major immediate-early genes in infected undifferentiated and differentiated cells
- Thrombin-induced p65 homodimer binding to downstream NF-kappa B site of the promoter mediates endothelial ICAM-1 expression and neutrophil adhesion.
- Roles of cytomegalovirus and Chlamydia trachomatis in the induction of cervical neoplasia in the mouse.
- Hepatitis B virus pX activates NF-kappa B-dependent transcription through a Raf-independent pathway
- A multivariate analysis of risk factors for cytomegalovirus infection in liver-transplant recipients.
- Human cytomegalovirus (HCMV) immediate-early enhancer/promoter specificity during embryogenesis defines target tissues of congenital HCMV infection
- The 21bp repeat element of the human cytomegalovirus major immediate early enhancer is a negative regulator of gene expression in undifferentiated cells.
- Multiple mechanisms are implicated in the regulation of NF-kappa B activity during human cytomegalovirus infection.
- Activation of protooncogene c-jun by the X protein of hepatitis B virus.
- HBx gene of hepatitis B virus induces liver cancer in transgenic mice
- The nucleotide sequence and reading frames of a mutant hepatitis B virus subtype adr.
- Cationic liposome-mediated transfection
- Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade.
- Reactivation of cytomegalovirus in patients with cirrhosis: Analysis of 122 cases
- Release of the hepatitis B virus-associated DNA polymerase from the viral particle by the proteolytic cleavage
- A positive regulatory sequence of hepatitis B viral small X promoter.
- Laboratory signs of acute or recent cytomegalovirus infection are common in cirrhosis of the liver
Cited by
- Biological impacts of "hot-spot" mutations of hepatitis B virus X proteins are genotype B and C differentiated.
- The cysteine residues of the hepatitis B virus onco-protein HBx are not required for its interaction with RNA or with human p53.
- NF-κB A Potential Therapeutic Target for Inhibition of Human Cytomegalovirus (Re)activation?
- Effects of inflammatory response on in vivo transgene expression by plasmid DNA in mice.
- CMV enhancer–promoter is preferentially active in exocrine cells in vivo
- Transcriptional Activation of Gammaherpesviral Oncogene Promoters by the Hepatitis B Viral X Protein (HBx)
- Transcriptome-Wide Analysis of Hepatitis B Virus-Mediated Changes to Normal Hepatocyte Gene Expression
- Effects of HSV-1 infection on disparate cell signaling pathways
- Improving transcriptional activity of human cytomegalovirus major immediate-early promoter by mutating NF-κB binding sites.
- RBM24 stabilizes hepatitis B virus pregenomic RNA but inhibits core protein translation by targeting the terminal redundancy sequence
- Voie de signalisation NF-kappaB dans la régulation de la transcription du VIH-1 et du HCMV dans les macrophages
- Tax Induces the Recruitment of NF-κB to Unintegrated HIV-1 DNA To Rescue Viral Gene Expression and Replication
- Analyzing the gene regulatory network in hepatitis B patients by single-cell ATAC sequencing
- Nucleolin binds to and regulates transcription of hepatitis B virus covalently closed circular DNA minichromosome
- Tax induces the recruitment of NF-kB to unintegrated HIV-1 DNA to rescue viral gene expression and replication
- Hepatitis B Virus X Protein: Structure-Function Relationships and Role in Viral Pathogenesis
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