TGF-β/BMP signaling and other molecular events: regulation of osteoblastogenesis and bone formation
Explore this paper's citation graph
Summary
Accumulating evidence indicates that Runx2 is the key integrator, whereas Hh is a possible modulator, miRNAs are regulators, and β-catenin is a mediator/regulator within the extensive intracellular network.
- Type
- review
- Published
- 2015-04-14
- Cited by
- 545
- References
- 188
- Access
- Open access
- OpenAlex
- https://openalex.org/W2019777614
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11531013
Keywords
Bone morphogenetic protein, BMPR2, Wnt signaling pathway, Cell biology, RUNX2
References
- Regulation of Bone Morphogenetic Protein Activity by Pro Domains and Proprotein Convertases
- Hairpin RNAs and Retrotransposon LTRs Effect RNAi and Chromatin-Based Gene Silencing
- Novel links among Wnt and TGF-beta signaling and Runx2.
- BMP-2-enhanced chondrogenesis involves p38 MAPK-mediated down-regulation of Wnt-7a pathway.
- The role of the activin receptor type IIb (ActRIIB) in glucose and energy homeostasis
- MicroRNAs: Synthesis, Gene Regulation and Osteoblast Differentiation.
- A soluble activin Type IIA receptor induces bone formation and improves skeletal integrity
- Recombinant human bone morphogenetic protein-2: a novel osteoinductive alternative to autogenous bone graft?
- The Hedgehog and Wnt signalling pathways in cancer
- Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis
- TGFβ–SMAD signal transduction: molecular specificity and functional flexibility
- Antagonism of Activin by Activin Chimeras
- BMP9 signaling in stem cell differentiation and osteogenesis.
- Cross‐talk between the bone morphogenetic protein pathway and other major signaling pathways results in tightly regulated cell‐specific outcomes
- TGF-β-induced epithelial to mesenchymal transition
- Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs).
- Bone Morphogenetic Protein (BMP) Type II Receptor Deletion Reveals BMP Ligand-specific Gain of Signaling in Pulmonary Artery Smooth Muscle Cells*
- Structure of the Bone Morphogenetic Protein Receptor ALK2 and Implications for Fibrodysplasia Ossificans Progressiva
- Structure of the ternary signaling complex of a TGF-β superfamily member
- BMP signaling in mesenchymal stem cell differentiation and bone formation
Cited by
- Pulsed electromagnetic fields stimulate osteogenic differentiation and maturation of osteoblasts by upregulating the expression of BMPRII localized at the base of primary cilium.
- Tuning of major signaling networks (TGF-β, Wnt, Notch and Hedgehog) by miRNAs in human stem cells commitment to different lineages: Possible clinical application.
- Circulating markers of bone turnover
- Zinc-modified Calcium Silicate Coatings Promote Osteogenic Differentiation through TGF-β/Smad Pathway and Osseointegration in Osteopenic Rabbits
- RGD Mutation of the Heparin Binding II Fragment of Fibronectin for Guiding Mesenchymal Stem Cell Behavior on Titanium Surfaces.
- Potentiated Osteoinductivity via Cotransfection with BMP-2 and VEGF Genes in Microencapsulated C2C12 Cells
- Targeting Yes‐associated Protein with Evolved Peptide Aptamers to Disrupt TGF‐β Signaling Pathway: Therapeutic Implication for Bone Tumor
- Macrophages in bone fracture healing: Their essential role in endochondral ossification.
- TGFβ signalling pathway regulates angiogenesis by endothelial cells, in an adipose‐derived stromal cell/endothelial cell co‐culture 3D gel model
- Rational design of YAP WW1 domain‐binding peptides to target TGFβ/BMP/Smad–YAP interaction in heterotopic ossification
- Pressuromodulation at the cell membrane as the basis for small molecule hormone and peptide regulation of cellular and nuclear function
- Smad signal pathway regulates angiogenesis via endothelial cell in an adipose-derived stromal cell/endothelial cell co-culture, 3D gel model
- Tea Polyphenol-Functionalized Graphene/Chitosan as an Experimental Platform with Improved Mechanical Behavior and Bioactivity.
- Skeletal Characterization of Smurf2-Deficient Mice and In Vitro Analysis of Smurf2-Deficient Chondrocytes
- Applications of Mesenchymal Stem Cells and Neural Crest Cells in Craniofacial Skeletal Research
- Stem Cells for Bone Regeneration: From Cell-Based Therapies to Decellularised Engineered Extracellular Matrices
- The Role of KV7.3 in Regulating Osteoblast Maturation and Mineralization
- Comparison of newly developed anti-bone morphogenetic protein 4 llama-derived antibodies with commercially available BMP4 inhibitors
- Mesenchymal Stem Cell Fate: Applying Biomaterials for Control of Stem Cell Behavior
- Bone morphogenetic protein signaling in musculoskeletal cancer
Related papers
- Novel bone morphogenetic protein (BMP)-2/4 consensus peptide (BCP) for the osteogenic differentiation of C2C12 cells.
- Upregulation of smpd3 via BMP2 stimulation and Runx2.
- Does BMPR2 mutation disrupt pulmonary vasculogenesis?
- Deletion of the Sequence Encoding the Tail Domain of the Bone Morphogenetic Protein type 2 Receptor Reveals a Bone Morphogenetic Protein 7-Specific Gain of Function
- [Evaluation of osteogenic effects of BMP2 up-regulator E40071 in vitro].
- Biological Mechanisms of Paeonoside in the Differentiation of Pre-Osteoblasts and the Formation of Mineralized Nodules
- Insight into Molecular Mechanism for Activin A-Induced Bone Morphogenetic Protein Signaling
- Enhancement of bone regeneration by gene delivery of BMP2/Runx2 bicistronic vector into adipose-derived stromal cells.
- Mechanism of Cyclic Tensile Stress in Osteogenic Differentiation of Human Periodontal Ligament Stem Cells
- Mullerian Inhibiting Substance Signaling Uses a Bone Morphogenetic Protein (BMP)-Like Pathway Mediated by ALK2 and Induces Smad6 Expression