Comparative pharmacokinetics and interspecies scaling of 3'-azido-3'-deoxythymidine (AZT) in several mammalian species.
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Summary
Results demonstrate that interspecies pharmacokinetic scaling can be used to estimate plasma AZT concentrations in humans and can be use to design initial dosage regimens.
- Type
- article
- Published
- 1990-03-01
- Cited by
- 35
- References
- 14
- Access
- Open access
- OpenAlex
- https://openalex.org/W2017997526
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:42083558
Keywords
Pharmacokinetics, Volume of distribution, Pharmacology, Plasma clearance, Allometry
References
- Interspecies correlation of plasma concentration history of methotrexate (NSC-740).
- Man versus beast: pharmacokinetic scaling in mammals.
- Human immunodeficiency viruses and the pathogenesis of AIDS.
- Pharmacokinetics and saturable renal tubular secretion of zidovudine in rats.
- Physiologically based pharmacokinetic modeling: principles and applications.
- 3′-Azido-2′,3′-Dideoxyuridine (AzddU): Comparative Pharmacokinetics with 3′-Azido-3′-Deoxythymidine (AZT) in Monkeys
- Quantitative Relations in the Physiological Constitutions of Mammals.
- 3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro.
- Similarity principles and intrinsic geometries: contrasting approaches to interspecies scaling.
- Dosage regimen design for pharmaceutical studies conducted in animals.
- Plasma and cerebrospinal fluid pharmacokinetics of 3′‐azido‐3′‐deoxythymidine: A Novel pyrimidine analog with potential application for the treatment of patients with AIDS and related diseases
- Comparative pharmacokinetics of 3'-azido-3'-deoxythymidine (AZT) and 3'-azido-2',3'-dideoxyuridine (AZddU) in mice.
- Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: evidence of a new acquired cellular immunodeficiency.
Cited by
- Interspecies comparisons of micronutrient requirements: metabolic vs. absolute body size.
- Feasibility of Developing a Neural Network for Prediction of Human Pharmacokinetic Parameters from Animal Data
- Probe Calibration in Transient Microdialysis In Vivo
- Toxicokinetics of 2',3'-didehydro-3'-deoxythymidine, stavudine (D4T).
- In vivo evaluation of zidovudine (AZT)-loaded ethylcellulose microspheres after oral administration in beagle dogs.
- The allometric approach for interspecies scaling of pharmacokinetic parameters.
- Application of Fixed Exponent 0.75 to the Prediction of Human Drug Clearance: An Inaccurate and Misleading Concept
- Pharmacokinetics of Anti‐HIV Nucleosides in Microswine
- Pharmacokinetics of zidovudine in cats.
- Interspecies Scaling and Pharmacokinetic Parameters of 3TC in Humans
- Role of fixed coefficients and exponents in the prediction of human drug clearance: how accurate are the predictions from one or two species?
- Prediction of Hepatic Metabolic Clearance Based on Interspecies Allometric Scaling Techniques and In Vitro-In Vivo Correlations
- Allometric principles for interspecies extrapolation in toxicological risk assessment--empirical investigations.
- Allometric scaling of xenobiotic clearance: Uncertainty versus universality
- Scaling basic toxicokinetic parameters from rat to man.
- PHARMACOKINETICS: MODEL STRUCTURE AND TRANSPORT SYSTEMS*
- The Prediction of Methylmercury Elimination Half-Life in Humans using Animal Data: A Neural Network/Rough Sets Analysis
- ALLOMETRIC SCALING FOR PREDICTING HUMAN DRUG CLEARANCE
- A global examination of allometric scaling for predicting human drug clearance and the prediction of large vertical allometry.
- Antiretroviral-Drug Concentrations in Semen: Implications for Sexual Transmission of Human Immunodeficiency Virus Type 1
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