Multiple Rare Alleles Contribute to Low Plasma Levels of HDL Cholesterol
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Summary
It is found that rare alleles with major phenotypic effects contribute significantly to low plasma HDL-C levels in the general population.
- Type
- article
- Published
- 2004-08-06
- Cited by
- 1,125
- References
- 14
- OpenAlex
- https://openalex.org/W2015849111
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:39429794
Keywords
Nonsynonymous substitution, Genetics, Biology, Allele, Population
References
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- The role of the ABCA1 transporter and cholesterol efflux in familial hypoalphalipoproteinemia Published, JLR Papers in Press, April 16, 2003. DOI 10.1194/jlr.M300080-JLR200
- Are rare variants responsible for susceptibility to complex diseases?
- Prediction of deleterious human alleles.
- The molecular pathology of lecithin:cholesterol acyltransferase (LCAT) deficiency syndromes.
- Decreased cellular cholesterol efflux is a common cause of familial hypoalphalipoproteinemia: role of the ABCA1 gene mutations.
- In-Depth Haplotype Analysis of ABCA1 Gene Polymorphisms in Relation to Plasma ApoA1 Levels and Myocardial Infarction
- High Density Lipoproteins, Reverse Transport of Cholesterol, and Coronary Artery Disease Insights From Mutations
- Efflux and Atherosclerosis
- ATVB In Focus Role of ABCA1 in Cellular Cholesterol Efflux and Reverse Cholesterol Transport
Cited by
- Genetics of Multiple Sclerosis
- Gene-sodium interaction and blood pressure: findings from genomics research of blood pressure salt sensitivity.
- Sequence variation in the human dopamine transporter gene in children with attention deficit hyperactivity disorder.
- Life, diversity and the pursuit of haplotypes
- The use of racial, ethnic, and ancestral categories in human genetics research.
- Schizophrenia: a common disease caused by multiple rare alleles
- Genetics of chronic obstructive pulmonary disease: a succinct review, future avenues and prospective clinical applications.
- Association of Genetic Variations of Regulator of G-Protein Signaling 2 with Hypertension in the General Xinjiang Kazakh Population
- Integrated Computational and Experimental Analysis of the Neuroendocrine Transcriptome in Genetic Hypertension Identifies Novel Control Points for the Cardio-Metabolic Syndrome
- Rare Variant Association Testing Under Low-Coverage Sequencing
- Introduction to genetics and genomics in asthma: genetics of asthma.
- A Robust Model-free Approach for Rare Variants Association Studies Incorporating Gene-Gene and Gene-Environmental Interactions
- Rare variant association studies: considerations, challenges and opportunities
- Pathway-based approach using hierarchical components of collapsed rare variants
- Genetics of Lipid and Lipoprotein Disorders and Traits
- Identification of Deleterious and Disease Alleles in a General Population and Preterm Labor Patients
- Understanding Human Demography And Its Implications For The Detection And Dynamics Of Natural Selection
- The Road to Identifying Disease Causing Genes: Association Tests, Genotype Imputations, and Sampling Strategies for Sequencing Studies.
- On the Allelic Architecture of Multiple Sclerosis in Sardinia
- Elucidating the genetic determinants of the archetypal complex disease hypertriglyceridemia
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