A model-based approach for determining orientations of biological macromolecules imaged by cryoelectron microscopy.

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Summary

A polar Fourier transform (PFT) method is described that facilitates determination and refinement of orientations of individual biological macromolecules imaged with cryoelectron microscopy techniques and a three-dimensional density map serves as a high signal-to-noise model.

Type
article
Published
1996-01-01
Cited by
391
References
63
Access
Open access

Keywords

Microscopy, Icosahedral symmetry, Biological system, Orientation (vector space), Symmetry (geometry)

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