Role of target geometry in phagocytosis.
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Summary
It is reported that particle shape, not size, plays a dominant role in phagocytosis, and particle size primarily impacts the completion of phagocytes in cases where particle volume exceeds the cell volume.
- Type
- article
- Published
- 2006-03-28
- Cited by
- 2,009
- References
- 22
- Access
- Open access
- OpenAlex
- https://openalex.org/W2015497529
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:29854332
Keywords
Phagocytosis, Cell biology, Particle (ecology), Biology, Biophysics
References
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- Actin dynamics during phagocytosis.
- Preparation and Characterization of Micrometer-Sized “Egg Shells”
- Preparation of monodisperse ellipsoidal polystyrene particles
- Biophysical aspects of microsphere engulfment by human neutrophils.
- Effect of the size and surface charge of polymer microspheres on their phagocytosis by macrophage.
- Particle size and surface charge affect particle uptake by human dendritic cells in an in vitro model.
- The regulation of actin polymerization and cross-linking in Dictyostelium.
- Live dynamics of Dictyostelium cofilin suggests a role in remodeling actin latticework into bundles.
- Cellular control of actin nucleation.
- Mechanisms of phagocytosis in macrophages.
Cited by
- Role of Actin, Myosin IB and Dynamin A in the Phagocytic Pathway of Dictyostelium discoideum
- Quantitative analysis of membrane remodeling at the phagocytic cup.
- Do membrane undulations help cells probe the world?
- Polymer particles that switch shape in response to a stimulus
- Top‐Down Fabrication of Polyelectrolyte‐Thermoplastic Hybrid Microparticles for Unidirectional Drug Delivery to Single Cells
- Nanoparticle vaccines.
- How half-coated janus particles enter cells.
- Using viruses as nanomedicines
- A Facile Synthesis of Dynamic, Shape Changing Polymer Particles
- Stealth nanotubes: strategies of shielding carbon nanotubes to evade opsonization and improve biodistribution
- Microsphere size influences the foreign body reaction.
- Non-Spherical Particles for Targeted Drug Delivery
- Multi-ligand functionalized particle design for cell targeting and drug delivery.
- Macrophages as Active Nanocarriers for Targeted Early and Adjuvant Cancer Chemotherapy.
- Preparation of wormlike polymeric nanoparticles coated with silica for delivery of methotrexate and evaluation of anticancer activity against MCF7 cells
- Exploring inhalable polymeric dry powders for anti-tuberculosis drug delivery.
- Host and parasite determinants of Leishmania survival following phagocytosis by macrophages
- Role of the class I Myosin, MyoK, and the actin binding protein 1, Abp1, in phagocytosis in dictyostelium discoideum
- Application of engineering principles to the design of biodegradable polymer matrices for controlled release
- Influence of particle shape on plasma protein adsorption and macrophage uptake.
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