Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors.
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Summary
Imatinib induced a sustained objective response in more than half of patients with an advanced unresectable or metastatic gastrointestinal stromal tumor, indicating that inhibition of the KIT signal-transduction pathway is a promising treatment for advanced gastrointestinalStromal tumors, which resist conventional chemotherapy.
- Type
- article
- Published
- 2002-08-15
- Cited by
- 4,312
- References
- 24
- Access
- Open access
- OpenAlex
- https://openalex.org/W2015015957
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:46098916
Keywords
Medicine, Imatinib, Imatinib mesylate, Tyrosine-kinase inhibitor, Tolerability
References
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- Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors.
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- Growth inhibition and modulation of kinase pathways of small cell lung cancer cell lines by the novel tyrosine kinase inhibitor STI 571
Cited by
- Gastrointestinal stromal tumors with exon 8 c-kit gene mutation might occur at extragastric sites and have metastasis-prone nature.
- Effects of systemic chemotherapy on the liver.
- Imatinib (Gleevec)-induced hepatotoxicity.
- Computational and experimental studies of protein kinase-inhibitor interactions
- Chemotherapy in soft tissue sarcomaThe Scandinavian Sarcoma Group experience
- GIST as the model of paradigm shift towards targeted therapy of solid tumors: update and perspective on trial design.
- Imatinib Mesylate
- Imatinib Attenuates Diabetes-Associated Atherosclerosis
- Imatinib therapy for hypereosinophilic syndrome and eosinophilia-associated myeloproliferative disorders.
- Plasma and Cerebrospinal Fluid Pharmacokinetics of Imatinib after Administration to Nonhuman Primates
- Targeting other abnormal signaling pathways in sarcoma: EGFR in synovial sarcomas, PPAR-gamma in liposarcomas.
- Revision of gastrointestinal mesenchymal tumours with CD117.
- Hypoglycemia in the Setting of Advanced Gastrointestinal Stromal Tumor
- Primäre Sarkome und Sarkommetastasen in der Leber
- Epithelioid Gastrointestinal Stromal Tumor With PDGFRA Activating Mutation and Immunoreactivity
- Effect of Tyrosine Kinase Inhibition Using Imatinib on Normal Lymphohematopoietic Cells
- Tyrosine kinases as targets for cancer therapy.
- Initial and late resistance to imatinib in advanced gastrointestinal stromal tumors are predicted by different prognostic factors: a European Organisation for Research and Treatment of Cancer-Italian Sarcoma Group-Australasian Gastrointestinal Trials Group study.
- Advanced gastrointestinal stromal tumor patients with complete response after treatment with imatinib mesylate.
- In vivo effects of imatinib mesylate on human haematopoietic progenitor cells
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