Prevalence of amplification of the oncogenes c-myc, HER2/neu, and int-2 in one thousand human breast tumours: correlation with steroid receptors.
Explore this paper's citation graph
Summary
Amplification of c-myc, HER2/neu and int-2/bcl-1 genes in a series of 1052 collected human breast tumours showed a large fluctuation, which could be attributed to the study of relatively small series of tumours, to selection of subgroups of patients, or, especially in retrospective studies, to Selection of tumour material from the tumour-bank.
- Type
- article
- Published
- 1992-02-01
- Cited by
- 139
- References
- 28
- OpenAlex
- https://openalex.org/W2014296185
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:43431490
Keywords
Gene duplication, Oncogene, INT, Breast cancer, Internal medicine
References
- Alterations to either c-erbB-2(neu) or c-myc proto-oncogenes in breast carcinomas correlate with poor short-term prognosis.
- The enhancing effect (or actively acquired tolerance) and the histocompatibility-2 locus in the mouse.
- Prognostic value of receptors for insulin-like growth factor 1, somatostatin, and epidermal growth factor in human breast cancer.
- Genetic alterations of c-myc, c-erbB-2, and c-Ha-ras protooncogenes and clinical associations in human breast carcinomas.
- Follow-up study of HER-2/neu amplification in primary breast cancer.
- Proto-oncogene abnormalities in human breast cancer: correlations with anatomic features and clinical course of disease.
- Chapter III. 1. Mutations in human breast cancer cells: Dominantly‐acting oncogenes and tumor suppressor genes suggest strategies for targeted interference
- Potential oncogene product related to growth factors
- A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.
- Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences
- 4. The role of the epidermal growth factor receptor and the c‐erbB‐2 protein in breast cancer
- Genetic alteration of the c-myc protooncogene (MYC) in human primary breast carcinomas.
- The neu oncogene encodes an epidermal growth factor receptor-related protein
- Int-1 and int-2: oncogenic proteins, mitogens and morphogens?
- c-erbB-2/c-erbA co-amplification indicative of lymph node metastasis, and c-myc amplification of high tumour grade, in human breast carcinoma.
- Cathepsin D assay in primary breast cancer and lymph nodes: relationship with c-myc, c-erb-B-2 and int-2 oncogene amplification and node invasiveness.
- A paradigm for oncogene complementation in human breast cancer.
- The neu gene: an erbB-homologous gene distinct from and unlinked to the gene encoding the EGF receptor.
- Analysis of the int-1, int-2, c-myc, and neu oncogenes in human breast carcinomas.
- Correlation between long-term survival in breast cancer patients and amplification of two putative oncogene-coamplification units: hst-1/int-2 and c-erbB-2/ear-1.
Cited by
- ErbB-2 oncoprotein overexpression in breast carcinoma: Inverse correlation with biochemically- and immunohistochemically-determined hormone receptors
- Quantitative determination of c-erbB-2 in human breast tumours: potential prognostic significance of low values.
- The Raf signal transduction cascade as a target for chemotherapeutic intervention in growth factor-responsive tumors.
- HER2 Is Frequently Over‐expressed in Ovarian Clear Cell Adenocarcinoma: Possible Novel Treatment Modality Using Recombinant Monoclonal Antibody against HER2, Trastuzumab
- Critical review of growth factors as clinical tools in primary and metastatic breast cancer.
- 1+1=? Combinations and combination strategies in early cancer-drug development
- Influence of c-myc on the progression of human breast cancer.
- What's new in breast cancer? Molecular perspectives of cancer development and the role of the oncogene c-erbB-2 in prognosis and disease.
- Prognostic Significance of Loss-of-Heterozygosity of the CUTL1 Putative Tumor Suppressor Gene in Breast Cancers
- Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer.
- Understanding the Metabolic and Genetic Regulation of Breast Cancer Recurrence Using Magnetic Resonance-Based Integrative Metabolomics
- The Role of Amplified Wild-Type Neu in the Etiology of Breast Cancer
- Improved classification of breast cancer by analysis of genetic alterations and gene expression profiling
- Potential for biomolecular imaging with femtosecond X-ray pulses
- Significance of HER2 and C‐MYC oncogene amplifications in breast cancer in atomic bomb survivors
- Tissue microarrays for gene amplification surveys in many different tumor types.
- Analysis of p53 and c-MYC, two key transcription factors involved in tumorigenesis
- Determination of c‐erbB‐2 Protein in Primary Breast Cancer Tissue Extract Using an Enzyme Immunoassay
- Bombesin antagonists inhibit growth of MDA-MB-435 estrogen-independent breast cancers and decrease the expression of the ErbB-2/HER-2 oncoprotein and c-jun and c-fos oncogenes
- Prognostic Factors and Proliferative Activities in Breast Cancer. A Comparative Study between Recurrent and Non-Recurrent Cases of Human Breast Carcinomas
Related papers
- Dommages-intérêts, intérêt positif et intérêt négatif
- Intérêt individuel, intérêt privé, intérêt commun - Les complications de la notion d’intérêt particulier
- Antisense oligonucleotides specific for the HER2/neu oncogene inhibit the growth of human breast carcinoma cells that overexpress HER2/neu.
- The N-terminal domain of EBNA1 acts as a suppressor of the HER2/neu oncogene.