Protection of ischemic hippocampal neurons by ginsenoside Rb1, a main ingredient of ginseng root.
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Summary
The findings suggest that the central infusion of ginsenoside Rb1 after forebrain ischemia protects hippocampal CA1 neurons against lethal ischemic damage possibly by scavenging free radicals which are overproduced in situ after brain ischemIA and reperfusion.
- Type
- article
- Published
- 1997-07-01
- Cited by
- 204
- References
- 36
- OpenAlex
- https://openalex.org/W2013995428
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:3909544
Keywords
Ginseng, Hippocampal formation, Neuroprotection, Ginsenoside, Ischemia
References
- Free radical damage of the brain following ischemia.
- Metal-catalyzed oxidation of proteins. Physiological consequences.
- Novel 21-amino steroids as potent inhibitors of iron-dependent lipid peroxidation.
- The involvement of iron in lipid peroxidation. Importance of ferric to ferrous ratios in initiation.
- Role of oxygen free radicals in carcinogenesis and brain ischemia
- PDGFs protect hippocampal neurons against energy deprivation and oxidative injury: evidence for induction of antioxidant pathways
- On the nature of biochemically generated hydroxyl radicals. Studies using the bleaching of p-nitrosodimethylaniline as a direct assay method.
- Protection by prosaposin against ischemia-induced learning disability and neuronal loss.
- Protective effect of basic fibroblast growth factor-heparin and neurotoxic effect of platelet factor 4 on ischemic neuronal loss and learning disability in gerbils.
- Rat mesencephalic neurons in culture exhibit different morphological traits in the presence of media conditioned on mesencephalic or striatal astroglia.
- Behavioral, electroencephalographic and histopathological studies on mongolian gerbils with occluded common carotid arteries.
- Interleukin-6 prevents ischemia-induced learning disability and neuronal and synaptic loss in gerbils.
- Trophic effects of interleukin-4, -7 and -8 on hippocampal neuronal cultures: potential involvement of glial-derived factors.
- Localization of gelsolin in myelin forming cells
- Transient forebrain ischemia of three-minute duration consistently induces severe neuronal damage in field CA1 of the hippocampus in the normothermic gerbil.
- Ginseng root prevents learning disability and neuronal loss in gerbils with 5-minute forebrain ischemia
- Free radicals in cerebral ischemia.
- Ciliary neurotrophic factor prevents ischemia-induced learning disability and neuronal loss in gerbils.
- Delayed neuronal death in the gerbil hippocampus following ischemia.
- Basic FGF, NGF, and IGFs Protect Hippocampal and Cortical Neurons against Iron-Induced Degeneration
Cited by
- Ginseng: potential for the enhancement of cognitive performance and mood.
- Polyphenols in cerebral ischemia
- Effects of ginsenosides on organogenesis and expression of glutathione peroxidase genes in cultured rat embryos.
- Ginsenoside Rg1 protects neurons from hypoxic-ischemic injury possibly by inhibiting Ca2+ influx through NMDA receptors and L-type voltage-dependent Ca2+ channels.
- [Status and progress of application of Chinese herbs in sports medicine].
- Medicinal Plant Extracts for the Treatment of Dementia
- Study of anti-Alzheimer Activities from Ginseng Radix Rubra Water Extract by Alzheimer's Protein APP-transgenic Fly
- Effect of Korea red ginseng on cerebral blood flow and superoxide production.
- Therapeutic Effects of Ginseng on Psychotic Disorders
- Ginsenosides and Their CNS Targets
- 돌발성난청에서 홍삼추출물의 추가적인 치료효과
- Cognitive improvement by ginseng in Alzheimer’s disease
- Therapeutic Use of Ginkgo Biloba
- 자외선 B 조사 마우스에서 피부손상에 대한 홍삼의 효과
- Complementary therapy for the treatment of glaucoma: a perspective.
- Effect of Red Ginseng on Radiation-induced Learning and Memory Impairment in Mouse
- Traditional Chinese herbal medicine for vascular dementia.
- Proteomic analysis reveals that the protective effects of ginsenoside Rb1 are associated with the actin cytoskeleton in β-amyloid-treated neuronal cells
- Selected herbals and human exercise performance.
- 백서의 피부 및 뇌혈류에 미치는 고려홍삼 사포닌 및 비사포닌의 영향
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