Progress and prospects: oligonucleotide-directed gene modification in mouse embryonic stem cells: a route to therapeutic application
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Summary
The significant progress that has been made over the last 5 years in unraveling the mechanisms and reaction parameters underlying ssODN-mediated gene targeting in murine embryonic stem cells and the impact of the DNA mismatch repair (MMR) system on the targeting process is discussed.
- Type
- review
- Published
- 2011-03-01
- Cited by
- 54
- References
- 81
- OpenAlex
- https://openalex.org/W2013876589
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11950956
Keywords
Biology, Embryonic stem cell, Genome editing, Gene targeting, Oligonucleotide
References
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- Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer.
- High efficiency mutagenesis, repair, and engineering of chromosomal DNA using single-stranded oligonucleotides
- Stable transmission of targeted gene modification using single-stranded oligonucleotides with flanking LNAs
- Targeted gene repair activates Chk1 and Chk2 and stalls replication in corrected cells.
- Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over
- Single-strand DNA-mediated targeted mutagenesis of genomic DNA in early mouse embryos is stimulated by Rad51/54 and by Ku70/86 inhibition
- Targeted correction of a chromosomal point mutation by modified single-stranded oligonucleotides in a GFP recovery system.
- Mutation in the mismatch repair gene Msh6 causes cancer susceptibility.
- DNA breakage associated with targeted gene alteration directed by DNA oligonucleotides
- Camptothecin enhances the frequency of oligonucleotide-directed gene repair in mammalian cells by inducing DNA damage and activating homologous recombination.
- Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells.
- Active transcription promotes single-stranded oligonucleotide mediated gene repair.
- Specific targeted gene repair using single-stranded DNA oligonucleotides at an endogenous locus in mammalian cells uses homologous recombination.
Cited by
- Regulation of Gene Editing Activity Directed by Single-Stranded Oligonucleotides and CRISPR/Cas9 Systems
- New approaches to the treatment of orphan genetic disorders: Mitigating molecular pathologies using chemicals.
- Oligonucleotide Delivery by Nucleofection Does Not Rescue the Reduced Proliferation Phenotype of Gene-Edited Cells
- The Mechanism of Gene Targeting in Human Somatic Cells
- Towards artificial metallonucleases for gene therapy: recent advances and new perspectives.
- Proliferation of Genetically Modified Human Cells on Electrospun Nanofiber Scaffolds
- Efficient and accurate homologous recombination in hESCs and hiPSCs using helper-dependent adenoviral vectors.
- The Position of DNA Cleavage by TALENs and Cell Synchronization Influences the Frequency of Gene Editing Directed by Single-Stranded Oligonucleotides
- Analysis of oligonucleotides by hydrophilic interaction liquid chromatography coupled to negative ion electrospray ionization mass spectrometry.
- Stable Gene Targeting in Human Cells Using Single-Strand Oligonucleotides with Modified Bases
- Combinatorial gene editing in mammalian cells using ssODNs and TALENs
- Targeted Gene Therapies: Tools, Applications, Optimization
- Emerging uses for pediatric hematopoietic stem cells
- Replicative DNA Polymerase δ but Not ε Proofreads Errors in Cis and in Trans
- A CRISPR approach to gene targeting.
- Transformation with Oligonucleotides Creating Clustered Changes in the Yeast Genome
- The mouse genetics toolkit: revealing function and mechanism
- Comparing ion-pairing reagents and sample dissolution solvents for ion-pairing reversed-phase liquid chromatography/electrospray ionization mass spectrometry analysis of oligonucleotides.
- Toward Multiplex Genome Engineering in Mammalian Cells
- DNA Damage Response Pathway and Replication Fork Stress During Oligonucleotide Directed Gene Editing
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