A New Model of Bilateral Hemispheric Ischemia in the Unanesthetized Rat
Explore this paper's citation graph
Summary
A new model of transient, bilateral hemispheric ischemia in the unanesthetized rat is described, with the ease of preparation of large numbers of animals, a high rate of predictable ischemic neuronal damage, a low incidence of seizures and the absence of anesthesia.
- Type
- article
- Published
- 1979-05-01
- Cited by
- 1,994
- References
- 34
- Access
- Open access
- OpenAlex
- https://openalex.org/W2013833441
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:5916340
Keywords
Medicine, Ischemia, Occlusion, Neocortex, Perfusion
References
- Anoxic-ischemic encephalopathy in rats.
- REGIONAL ENERGY RESERVES IN MOUSE BRAIN AND CHANGES WITH ISCHAEMIA AND ANAESTHESIA *
- A combined light and electron microscope study of early anoxic-ischaemic cell change in rat brain.
- Graded hypoxia-oligemia in rat brain. II. Neuropathological alterations and their implications.
- Collagen biosynthesis in blood vessels of brain and other tissues of the hypertensive rat
- Biochemical alterations in the anoxic-ischemic lesion of rat brain.
- Graded hypoxia-oligemia in rat brain. I. Biochemical alterations and their implications.
- The influence of arterial hypoxia and unilateral carotid artery occlusion upon regional blood flow and metabolism in the rat brain.
- PRIMATE MODEL OF CEREBRAL HEMATOMA
- The Mongolian gerbil (Meriones unguiculatus) as a model for the study of the epilepsies: EEG records of seizures.
- Cerebral Protection by Thiopental during Hypoxia
- The effect of bilateral carotid artery ligation upon the blood flow and the energy state of the rat brain.
- Postischemic cerebral blood flow and oxygen utilization rate in rats anesthetized with nitrous oxide or phenobarbital.
- Cerebral metabolic state following complete compression ischemia.
- The influence of arterial hypoxemia upon labile phosphates and upon extracellular and intracellular lactate and pyruvate concentrations in the rat brain.
- Barbiturate protection in cerebral hypoxia.
- Anoxic-ischaemic cell change in rat brain light microscopic and fine-structural observations.
- Autoregulation of Cerebral Blood Flow in Hypertensive Patients: The Modifying Influence of Prolonged Antihypertensive Treatment on the Tolerance to Acute, Drug‐induced Hypotension
- Epileptic seizures in nonembolic cerebral infarction.
- Ischaemic brain damage in the gerbil in the absence of 'no-reflow'.
Cited by
- Neural Stem Cell Grafts and the Influence of Apolipoprotein E in a Mouse Model of Global Ischaemia
- Neuronal damage and calcium accumulation following transient cerebral ischemia in the rat.
- Binding of [3H]inositoltrisphosphate and [3H]phorbol 12,13-dibutyrate in rat hippocampus following transient global ischemia: a quantitative autoradiographic study.
- Lesions to Schaffer collaterals prevent ischemic death of CA1 pyramidal cells.
- Morphological lesions in the brain preceding the development of postischemic seizures
- Rapid down regulation of hippocampal adenosine receptors following brief anoxia.
- Recovery from focal brain ischemia induced by extradural compression in diabetic and non-diabetic rats
- Calcium/calmodulin-dependent protein kinase II and protein phosphatase 2B (calcineurin) immunoreactivity in the rat hippocampus long after ischemia.
- Treatment with an AMPA Antagonist 12 Hours following Severe Normothermic Forebrain Ischemia Prevents CA1 Neuronal Injury
- Transient ischemia causes a reduction of Mg2+ blockade of NMDA receptors.
- Four modified silver methods for thick sections of formaldehyde-fixed mammalian central nervous tissue: 'dark' neurons, perikarya of all neurons, microglial cells and capillaries.
- Ubiquitin Activity Following Forebrain Ischemia/Reperfusion in the Rat
- Long-term structural and biochemical events in the hippocampus following transient global ischemia.
- Ischemic tolerance due to the induction of HSP70 in a rat ischemic recirculation model.
- Levemopamil reduces spatial learning deficit following transient occulusion of common carotid arteries in normotensive rats
- Decrease in amyloid precursor protein precedes hippocampal degeneration in rat brain following transient global ischemia.
- Synchronicity of nociceptive and non-nociceptive adjacent neurons in the spinal dorsal horn of the rat: stimulus-induced plasticity.
- Morphofunctional effects of moderate forebrain ischemia combined with short-term hypoxia in rats--protective effects of Cerebrolysin.
- Murine models of brain aging and age-related neurodegenerative diseases.
- Global cerebral ischemia activates nuclear factor-kappa B prior to evidence of DNA fragmentation.
Related papers
- Embryonic mouse medial neocortex as a model system for studying the radial glial scaffold in fetal human neocortex
- Neocortex in early mammals and its subsequent variations
- Fez1 is layer‐specifically expressed in the adult mouse neocortex
- Human-specific ARHGAP11B induces hallmarks of neocortical expansion in developing ferret neocortex
- Human-specific ARHGAP11B induces hallmarks of neocortical expansion in developing ferret neocortex
- Infant posterior neocortical lesions do not induce visual responses in spared anterior neocortex
- Primatenspezifische Gene als Determinanten der Neokortexmorphologie
- Free Radical Reactions after Permanent and Reversible Middle Cerebral Artery Occlusion in Rats