Novel proteinaceous infectious particles cause scrapie.
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Summary
A new term "prion" is proposed to denote a small proteinaceous infectious particle which is resistant to inactivation by most procedures that modify nucleic acids.
- Type
- article
- Published
- 1982-04-09
- Cited by
- 5,052
- References
- 109
- OpenAlex
- https://openalex.org/W2013679718
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7447120
Keywords
Scrapie, Infectious agent, Infectivity, Nucleic acid, Virology
References
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- DNA packaging by the double-stranded DNA bacteriophages.
- Scrapie: a modified membrane hypothesis.
- Scrapie: A transmissible and hereditary disease of sheep
- Thiocyanate and hydroxyl ions inactivate the scrapie agent.
Cited by
- Further analysis of nucleic acids in purified scrapie prion preparations by improved return refocusing gel electrophoresis.
- Copurification of Sp33-37 and scrapie agent from hamster brain prior to detectable histopathology and clinical disease.
- Bovine Spongiform Encephalopathy: A Neuropathological Perspective
- Ultrastructural studies of prions.
- Are prions misfolded molecular chaperones?
- Potential retroviral RNAs in Creutzfeldt-Jakob disease
- Positron emission tomography in Creutzfeldt-Jakob disease.
- Viruses as toxins
- Genetics and polymorphism of the mouse prion gene complex: control of scrapie incubation time
- Prions are novel infectious pathogens causing scrapie and Creutzfeldt-Jakob disease.
- PrP interactions with nucleic acids and glycosaminoglycans in function and disease.
- Morphogenesis of amyloid plaques in mice with Creutzfeldt-Jakob disease
- Characterization of lipids in membrane vesicles from scrapie-infected hamster brain.
- Neurodegeneration in humans caused by prions.
- Prions: novel infectious pathogens.
- Human prion diseases and neurodegeneration.
- Acquired immune deficiency syndrome (AIDS). Hypotheses on the etiology.
- Experimental oral transmission of chronic wasting disease to red deer (Cervus elaphus elaphus): early detection and late stage distribution of protease-resistant prion protein.
- Mechanisms of Multivesicular Body Biogenesis and Exosome Release
- The apolipoprotein E alleles as major susceptibility factors for Creutzfeldt-Jakob disease. The French Research Group on Epidemiology of Human Spongiform Encephalopathies.
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