Chromatin unfolding by Cdt1 regulates MCM loading via opposing functions of HBO1 and HDAC11-geminin

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Summary

It is shown that Cdt1 induces large scale chromatin decondensation that is required for MCM recruitment and that chromatin at endogenous origins is more accessible in G1 relative to S-phase, providing evidence that histone acetylation promotes MCM loading via enhanced chromatin accessibility.

Type
article
Published
2010-11-01
Cited by
75
References
177
Access
Open access

Keywords

DNA replication factor CDT1, Biology, Cell biology, Chromatin, Histone

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