Chromatin unfolding by Cdt1 regulates MCM loading via opposing functions of HBO1 and HDAC11-geminin
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Summary
It is shown that Cdt1 induces large scale chromatin decondensation that is required for MCM recruitment and that chromatin at endogenous origins is more accessible in G1 relative to S-phase, providing evidence that histone acetylation promotes MCM loading via enhanced chromatin accessibility.
- Type
- article
- Published
- 2010-11-01
- Cited by
- 75
- References
- 177
- Access
- Open access
- OpenAlex
- https://openalex.org/W2013407554
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11114700
Keywords
DNA replication factor CDT1, Biology, Cell biology, Chromatin, Histone
References
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- Control of chromosomal DNA replication in the early Xenopus embryo
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- FACT facilitates chromatin transcription by RNA polymerases I and III
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- G1 events and regulation of cell proliferation.
Cited by
- Histone Deacetylases as Targets for Melanoma Immunotherapy
- Rationale for HDAC inhibitor therapy in autoimmunity and transplantation.
- Analysis of DNA replication associated chromatin decondensation: in vivo assay for understanding chromatin remodeling mechanisms of selected proteins.
- Geminin overexpression induces mammary tumors via suppressing cytokinesis
- Embryonic Stem Cells License a High Level of Dormant Origins to Protect the Genome against Replication Stress
- An Inactive Geminin Mutant That Binds Cdt1
- SCFFbxw15 Mediates Histone Acetyltransferase Binding to Origin Recognition Complex (HBO1) Ubiquitin-Proteasomal Degradation to Regulate Cell Proliferation*
- Molecular Characterization, Polymorphism, and Association of Porcine GADD45G Gene
- Geminin Inhibits a Late Step in the Formation of Human Pre-replicative Complexes
- Epigenetic landscape for initiation of DNA replication
- The Geminin and Idas Coiled Coils Preferentially Form a Heterodimer That Inhibits Geminin Function in DNA Replication Licensing
- A chromatin perspective of plant cell cycle progression.
- JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress
- Looking at plant cell cycle from the chromatin window
- HDAC inhibitor therapy in autoimmunity and transplantation
- Licensing of DNA replication, cancer, pluripotency and differentiation: an interlinked world?
- The histone acetyltransferases CBP and Chameau integrate developmental and DNA replication programs in Drosophila ovarian follicle cells
- p16 Gene Transfer Induces Centrosome Amplification and Abnormal Nucleation Associated with Survivin Downregulation in Glioma Cells
- Cdt1 Is Differentially Targeted for Degradation by Anticancer Chemotherapeutic Drugs
- Progress in understanding DNA replication control.
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- Chromatin fractionation analysis of licensing factors in mammalian cells.
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