Recognition of the polyubiquitin proteolytic signal
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Summary
The properties of the substrates studied here implicate substrate unfolding as a kinetically dominant step in the proteolysis of properly folded proteins, and suggest that extraproteasomal chaperones are required for efficient degradation of certain proteasome substrates.
- Type
- article
- Published
- 2000-01-04
- Cited by
- 1,891
- References
- 64
- Access
- Open access
- OpenAlex
- https://openalex.org/W2013339424
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:10350482
Keywords
Proteolysis, Biology, Ubiquitin, Proteasome, Cell biology
References
- Inhibition of the 26 S Proteasome by Polyubiquitin Chains Synthesized to Have Defined Lengths*
- Endoplasmic reticulum degradation: reverse protein flow of no return
- How the cyclin became a cyclin: Regulated proteolysis in the cell cycle
- FURTHER STUDIES ON DIHYDROFOLIC REDUCTASE.
- Ubiquitin as a degradation signal.
- The 26S proteasome.
- Recognition of modified forms of ribonuclease A by the ubiquitin system.
- Mechanism of ubiquitin carboxyl-terminal hydrolase. Borohydride and hydroxylamine inactivate in the presence of ubiquitin.
- A 26 S protease subunit that binds ubiquitin conjugates.
- Ubiquitin‐dependent internalization and down‐regulation of plasma membrane proteins
- Multiple forms of the 20 S multicatalytic and the 26 S ubiquitin/ATP-dependent proteases from rabbit reticulocyte lysate.
- Universality and structure of the N-end rule.
- The yeast ubiquitin genes: a family of natural gene fusions.
- Ubiquitin and the Biology of the Cell
- Cdc48p interacts with Ufd3p, a WD repeat protein required for ubiquitin‐mediated proteolysis in Saccharomyces cerevisiae.
- A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p.
- Multiubiquitin Chain Binding and Protein Degradation Are Mediated by Distinct Domains within the 26 S Proteasome Subunit Mcb1*
- Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 A resolution.
- Degradation of oxidized insulin B chain by the multiproteinase complex macropain (proteasome).
- A Proteolytic Pathway That Recognizes Ubiquitin as a Degradation Signal (*)
Cited by
- Investigating the combined burden of transcription and quality control errors in yeast
- The proteasome: a supramolecular assembly designed for controlled proteolysis.
- A NOVEL CLASS OF IMMUNOPROTEASOME CATALYTIC SUBUNIT LMP2 INHIBITOR AND ITS THERAPEUTIC POTENTIALS IN CANCER
- Extracellular Ubiquitin: Role in Myocyte Apoptosis and Myocardial Remodeling
- Kaposi's Sarcoma-Associated Herpesvirus K7 Protein Targets a Ubiquitin-Like/Ubiquitin-Associated Domain-Containing Protein To Promote Protein Degradation
- Recognition and processing of misfolded proteins by PA700, the 19S regulatory complex of the 26S proteasome.
- The ubiquitin-proteasome pathway and its role in cancer.
- Structure and mechanisms of the proteasome‐associated deubiquitinating enzyme USP14
- The proteasome: a novel target for anticancer therapy
- E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system.
- Cell cycle-dependent caspase-like activity that cleaves p27(KIP1) is the beta(1) subunit of the 20S proteasome.
- Recognition of Polyubiquitin Isoforms by the Multiple Ubiquitin Binding Modules of Isopeptidase T*
- Cross‐species divergence of the major recognition pathways of ubiquitylated substrates for ubiquitin/26S proteasome‐mediated proteolysis
- Constructing and decoding unconventional ubiquitin chains
- The ubiquitin proteasome system in neurodegenerative diseases: culprit, accomplice or victim?
- The lysine48-based polyubiquitin chain proteasomal signal: not a single child anymore.
- Role of C/EBPβ-LAP and C/EBPβ-LIP in early adipogenic differentiation of human white adipose-derived progenitors and at later stages in immature adipocytes.
- Protein lysine‐Nζ alkylation and O‐phosphorylation mediated by DTT‐generated reactive oxygen species
- A Conserved Protein with AN1 Zinc Finger and Ubiquitin-like Domains Modulates Cdc48 (p97) Function in the Ubiquitin-Proteasome Pathway*
- Critical and Independent Roles of the P/CAF Acetyltransferase in ARF-p53 Signaling: A Dissertation
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