Reduced Endoplasmic Reticulum Luminal Calcium Links Saturated Fatty Acid-Mediated Endoplasmic Reticulum Stress and Cell Death in Liver Cells
Explore this paper's citation graph
Summary
The data suggest that redistribution of ER luminal calcium contributes to long chain saturated fatty acid-mediated ER stress and cell death.
- Type
- article
- Published
- 2009-05-15
- Cited by
- 146
- References
- 43
- Access
- Open access
- OpenAlex
- https://openalex.org/W2013281318
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:11778379
Keywords
Endoplasmic reticulum, Unfolded protein response, Thapsigargin, Calcium, Programmed cell death
References
- HIGH-YIELD PREPARATION OF ISOLATED RAT LIVER PARENCHYMAL CELLS
- Nutritional and Metabolic Considerations in the Etiology of Nonalcoholic Steatohepatitis
- Processing of gene expression data generated by quantitative real-time RT-PCR.
- Decreased cardiolipin synthesis corresponds with cytochrome c release in palmitate-induced cardiomyocyte apoptosis.
- Effects of type 2 diabetes mellitus on plasma fatty acid composition and cholesterol content of erythrocyte and leukocyte membranes
- Nonalcoholic fatty liver disease: an underrecognized cause of cryptogenic cirrhosis.
- The Endoplasmic Reticulum: Folding, Calcium Homeostasis, Signaling, and Redox Control
- Transcriptional Regulation of Bim by FoxO3A Mediates Hepatocyte Lipoapoptosis*
- Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells.
- Palmitate-induced Apoptosis Can Occur through a Ceramide-independent Pathway*
- Lack of Mitochondrial Anionic Phospholipids Causes an Inhibition of Translation of Protein Components of the Electron Transport Chain
- Free fatty acids promote hepatic lipotoxicity by stimulating TNF‐α expression via a lysosomal pathway
- Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease.
- Intraluminal calcium as a primary regulator of endoplasmic reticulum function.
- Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
- Caspase and calpain function in cell death: bridging the gap between apoptosis and necrosis
- Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis.
- Insulin protects liver cells from saturated fatty acid-induced apoptosis via inhibition of c-Jun NH2 terminal kinase activity.
- O0040 FREE FATTY ACIDS PROMOTE HEPATIC LIPOTOXICITY BY STIMULATING TNF‐ALPHA EXPRESSION VIA A LYSOSOMAL PATHWAY
- Triglyceride accumulation protects against fatty acid-induced lipotoxicity
Cited by
- Role of unfolded protein response in lipogenesis.
- HDLs protect the MIN6 insulinoma cell line against tunicamycin-induced apoptosis without inhibiting ER stress and without restoring ER functionality.
- A nonalcoholic fatty liver disease model in human induced pluripotent stem cell-derived hepatocytes, created by endoplasmic reticulum stress-induced steatosis
- Elongation factor 1A-1 and hepatocyte response to fatty acid excess
- The contribution of vascular adhesion protein-1 to glucose and lipid homeostasis in the liver
- Modulation of skeletal muscle insulin sensitivity and SNAT2 amino acid transporter expression by fatty acid availability
- Regulation of podocyte survival and endoplasmic reticulum stress by fatty acids and its modification by Stearoyl-CoA desaturases and cyclic AMP
- Pharmacological ER stress promotes hepatic lipogenesis and lipid droplet formation.
- Invited review: Inflammation during the transition to lactation: New adventures with an old flame.
- Long-chain fatty acids and endoplasmic reticulum stress in pancreatic beta-cells: the role of Protein Kinase R (PKR)
- Lipotoxicity in the liver.
- Alleviation mechanisms against hepatocyte oxidative stress in patients with chronic hepatic disorders
- Integration of ER stress, oxidative stress and the inflammatory response in health and disease.
- Consequences of non-alcoholic fatty liver disease on drug-induced hepatocytoxicity.
- Calcium Signaling in the Liver
- Characterization of fatty acid profile in the liver of SHR/NDmcr-cp (cp/cp) rats, a model of the metabolic syndrome.
- Pharmacological correction of obesity-induced autophagy arrest using calcium channel blockers
- Activation of the endoplasmic reticulum unfolded protein response by lipid disequilibrium without disturbed proteostasis in vivo
- Palmitoleate attenuates palmitate-induced bim and PUMA up-regulation and hepatocyte lipoapoptosis
- Decreased expression of endoplasmic reticulum chaperone GRP78 in liver of diabetic mice.
Related papers
- Lipotoxic endoplasmic reticulum stress, β cell failure, and type 2 diabetes mellitus.
- ER Stress에 의해 유발된 C6 Glial Cells의 손상에 대한 용뇌(龍腦)의 보호효과
- The regulatory mechanism of 4-phenylbutyric acid against ER stress-induced autophagy in human gingival fibroblasts
- Thapsigargin down‐regulates protein levels of GRP78/BiP in INS‐1E cells
- The unfolded protein response in melanocytes: activation in response to chemical stressors of the endoplasmic reticulum and tyrosinase misfolding
- Ethanol down‐regulates microglia inflammatory responses augmented by endoplasmic reticulum stress
- SEC24A identified as an essential mediator of thapsigargin-induced cell death in a genome-wide CRISPR/Cas9 screen