A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif
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Summary
A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the identification of a new gene, termed SRY (for sex-determining region Y) and proposed to be a candidate for the elusive testis-d determining gene, TDF.
- Type
- article
- Published
- 1990-07-19
- Cited by
- 3,220
- References
- 33
- Access
- Open access
- OpenAlex
- https://openalex.org/W2013246689
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4364032
Keywords
Schizosaccharomyces pombe, Gene, Homology (biology), Biology, Genetics
References
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- Assignment of the gene encoding the beta‐subunit of the human fibronectin receptor (β‐FNR) to chromosome 10p11.2
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- Two‐dimensional gel analysis of the polypeptides precipitated by a polymorphic HLA‐DR1,2,w6 monoclonal antibody: Evidence for a third locus
- Human XX males with Y single-copy DNA fragments
- ZFX has a gene structure similar to ZFY, the putative human sex determinant, and escapes X inactivation.
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- New method for mapping genes in human chromosomes
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- Male sexual differentiation in mice lacking H–Y antigen
- Induction by torsional stress of an altered DNA conformation 5' upstream of the gene for a high mobility group protein from trout and specific binding to flanking sequences by the gene product HMG-T.
- The sex-determining region of the human Y chromosome encodes a finger protein.
Cited by
- The role of Sry in mammalian sex determination.
- Normal postnatal androgen production and action in isolated micropenis and isolated hypospadias.
- Synthesizing embryology and human genetics: paradigms regained.
- The cell biology and molecular genetics of testis determination.
- Caracterización de la variabilidad genética en las razas de cerdos chinos y europeos. El proyecto PIGBIODIV2
- Interaction between a novel F9-specific factor and octamer-binding proteins is required for cell-type-restricted activity of the fibroblast growth factor 4 enhancer
- Clinical and genetic variability in XX sex-reversed patients.
- A novel postzygotic nonsense mutation in SRY in familial XY gonadal dysgenesis
- Cloning and mapping of bovine ZFX gene to the long arm of the X-chromosome (Xq34) and homologous mapping of ZFY gene to the distal region of the short arm of the bovine (Yp13), ovine (Yp12–p13), and caprine (Yp12–p13) Y Chromosome
- Evidence for specific RNA/protein interactions in the differential segment of the W sex chromosome in the amphibian Pleurodeles waltl
- Interactions between SRY and SOX genes in mammalian sex determination.
- Y‐chromosome identification by PCR and gonadal histopathology in Turner's syndrome without overt Y‐mosaicism
- A heuristic approach of maximum likelihood method for inferring phylogenetic tree and an application to the mammalian SOX‐3 origin of the testis‐determining gene SRY
- SRY Interacts with and Negatively Regulates Androgen Receptor Transcriptional Activity*
- Cellular and molecular pathways regulating mammalian sex determination.
- The Genetic Basis for Sex Differences in Human Behaviour: Role of the Sex Chromosomes
- Generation of antibodies against DMRT1 and DMRT4 of Oreochromis aurea and analysis of their expression profile in Oreochromis aurea tissues.
- Testicular Morphogenesis
- Extended Pedigree with Multiple Cases of XX Sex Reversal in the Absence of SRY and of a Mutation at the SOX9 Locus
- Cloning and expression of candidate sexual development genes in the cane toad (Bufo marinus)
Related papers
- 46,XX Male Disorder of Sexual Development: A Case Report
- Familial case of 46,XX male and 46,XX true hermaphrodite associated with a paternal-derived SRY-bearing X chromosome.
- DETECTION OF THE SRY AND ZFY SLQUENCES IN PATIENTS WITH ABNORMAL GORADAL DIFFERENTIATION
- Molecular sexing in Bos taurus using quantitative polymerase chain reaction (qPCR) method
- Clinical, Hormonal and Cytogenetic Evaluation of 46,XX Males and Review of the Literature
- Investigation of SRY Gene in Sex Reversed Syndrome Patients
- Genetic evidence equating SRY and the testis-determining factor
- Male-biased distribution of the human Y chromosomal genes SRY and ZFY in the lizard Calotes versicolor, which lacks sex chromosomes and temperature-dependent sex determination
- The SRY protein, like HMG 1, recognizes (CA)n sequences, an abundant repeat sequence in vertebrates.
- The biochemical role of SRY in sex determination