Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4
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Summary
Calcium signalling induces an association between NF-AT4 and calcineurin, and that these molecules are transported, as a complex, to the nucleus, where calcineURin continues to dephosphorylate NF- AT4.
- Type
- article
- Published
- 1996-07-25
- Cited by
- 509
- References
- 25
- OpenAlex
- https://openalex.org/W2013056080
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:4341818
Keywords
Calcineurin, Dephosphorylation, Transcription factor, Nuclear transport, Kinase
References
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- Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.
- X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex.
- Direct Demonstration of NFATp Dephosphorylation and Nuclear Localization in Activated HT-2 Cells Using a Specific NFATp Polyclonal Antibody (*)
Cited by
- Interactions of human cytomegalovirus proteins with the nuclear transport machinery.
- RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein.
- Evidence that calcineurin is rate-limiting for primary human lymphocyte activation.
- A calcium microdomain near NMDA receptors: on switch for ERK-dependent synapse-to-nucleus communication
- Negative regulation and gain control of sensory neurons by the C. elegans calcineurin TAX-6.
- Excitation-Transcription Coupling: Signaling by Ion Channels to the Nucleus
- Dual Roles for NFAT Transcription Factor Genes as Oncogenes and Tumor Suppressors
- Inhibition of Nuclear Translocation of Calcineurin Suppresses T-Cell Activation and Prevents Acute Rejection of Donor Hearts
- Dose‐Dependent Transcriptional Regulation by the Calcineurin/NFAT Signaling in Developing Myocardium Transition
- TGF-β-Smad2 dependent activation of CDC 25A plays an important role in cell proliferation through NFAT activation in metastatic breast cancer cells.
- Cell cycle and apoptosis regulation by NFAT transcription factors: new roles for an old player
- IP3R-mediated Ca2+ signals govern hematopoietic and cardiac divergence of Flk1+ cells via the calcineurin–NFATc3–Etv2 pathway
- Aberrant Signaling Pathways in T-Cell Acute Lymphoblastic Leukemia
- Pathophysiological relevance of forkhead transcription factors in brain ischemia.
- Muscle A-kinase–anchoring protein-β–bound calcineurin toggles active and repressive transcriptional complexes of myocyte enhancer factor 2D
- Peptidyl-prolyl cis-trans Isomerases in the Chloroplast Thylakoid Lumen
- Galectin-3 Enhances the Malignant Melanoma Phenotype by Regulating Autotaxin
- Redox regulation of protein serine/threonine phosphatase calcineurin
- Molecular Regulation of Cytokine Gene Expression During the Immune Response
- Genetic analysis of B cell signaling.
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