An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiation
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Summary
It is found that intracellular injection into CA1 pyramidal cells of the protein kinase inhibitor H-7, or of the calmodulin antagonist calmidazolium, blocks LTP, and LTP is blocked by the injection of synthetic peptides that are potentCalmodulin antagonists and inhibit CaM-KII auto- and substrate phosphorylation.
- Type
- article
- Published
- 1989-08-17
- Cited by
- 1,035
- References
- 39
- OpenAlex
- https://openalex.org/W2012974904
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:20325264
Keywords
Long-term potentiation, Postsynaptic potential, Excitatory postsynaptic potential, Chemistry, Postsynaptic density
References
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- Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C.
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- Interaction of calmodulin inhibitors and protein kinase C inhibitors with voltage-dependent calcium channels.
- Postsynaptic calcium is sufficient for potentiation of hippocampal synaptic transmission.
- Magnesium gates glutamate-activated channels in mouse central neurones
- Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones
- Persistent protein kinase activity underlying long-term potentiation
- NMDA application potentiates synaptic transmission in the hippocampus
- Trifluoperazine inhibits hippocampal long-term potentiation and the phosphorylation of a 40,000 dalton protein.
- Temporally distinct pre- and post-synaptic mechanisms maintain long-term potentiation
- Intracellular injections of EGTA block induction of hippocampal long-term potentiation
- Regulation of brain type II Ca2+/calmodulin-dependent protein kinase by autophosphorylation: a Ca2+-triggered molecular switch.
- Translocation of protein kinase C activity may mediate hippocampal long-term potentiation.
- Phospholipid-sensitive Ca2+-dependent protein kinase: a major protein phosphorylation system.
Cited by
- Primary and Secondary Ca2+ Concentration Changes Resulting from Transmitter Stimulation in Dendrites of Neurons from the Mammalian Hippocampus a
- GABAB receptor stimulation by baclofen and taurine enhances excitatory amino acid induced phosphatidylinositol turnover in neonatal rat cerebellum.
- Calcium/calmodulin-dependent protein kinase II and protein phosphatase 2B (calcineurin) immunoreactivity in the rat hippocampus long after ischemia.
- Mechanism for a sliding synaptic modification threshold.
- Modulation of a neuronal calmodulin mRNA species in the rat brain stem by reserpine
- A role of Ca2+/calmodulin-dependent protein kinase II in the induction of long-term potentiation in hippocampal CA1 area.
- Protein Kinases in the Rat Nucleus Accumbens are Involved in the Aversive Component of Opiate Withdrawal
- Duration of NMDA-dependent synaptic potentiation in piriform cortex in vivo is increased after epileptiform bursting.
- Flies put the buzz back into long-term-potentiation
- Long-term potentiation in bone – a role for glutamate in strain-induced cellular memory?
- Inhibition of Caspase-3 Blocks Long-Term Potentiation in Hippocampal Slices
- Phosphorylation of the AMPAR-TARP Complex in Synaptic Plasticity
- Antiserum Against S-100 Protein Prevents Long Term Potentiation Through a cAMP-Related Mechanism
- Postsynaptic signaling mechanisms by the NMDA-Receptor and CaMKII
- A role for calcium/calmodulin-dependent protein kinase II in cardiac disease and arrhythmia.
- Ca2+-Independent Autophosphorylation of Postsynaptic Density-Associated Ca2+/Calmodulin-Dependent Protein Kinase
- Régulation de la traduction des ARNm dendritiques par des ribonucléoprotéines et Rôle de CHMP2B dans la morphogenèse des épines dendritiques
- Papel da proteína cinase C (PKC) no processamento de memórias aversivas e espaciais
- The effect of neurotrophic factors on spiral ganglion neurons
- NMDA RECEPTORS IN THE DORSAL VAGAL COMPLEX OF NORMAL AND DIABETIC MICE
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