The importance of insulin resistance in the pathogenesis of type 2 diabetes mellitus.
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Summary
Although little can be done to avert a genetic predisposition to type 2 diabetes, normoglycemia can be preserved in individuals who remain insulin sensitive and lifestyle changes can be implemented and medications can be administered to improve insulin sensitivity, insulin secretion, and glucose utilization and reduce the prevalence of type 1 diabetes.
- Type
- review
- Published
- 2000-04-17
- Cited by
- 186
- References
- 14
- OpenAlex
- https://openalex.org/W2012655679
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:23931280
Keywords
Insulin resistance, Medicine, Insulin, Type 2 diabetes, Hyperinsulinemia
References
- Glucose intolerance and diabetic complications among Japanese-American women.
- Global Burden of Diabetes, 1995–2025: Prevalence, numerical estimates, and projections
- Plasma insulin levels in Japanese and Japanese-American men with type 2 diabetes may be related to the occurrence of cardiovascular disease.
- Earlier Appearance of Impaired Insulin Secretion Than of Visceral Adiposity in the Pathogenesis of NIDDM: 5-Year Follow-up of Initially Nondiabetic Japanese-American Men
- Determinants of Diabetes Mellitus in the Pima Indians
- Prevalence of Diabetes in Mexican Americans, Cubans, and Puerto Ricans From the Hispanic Health and Nutrition Examination Survey, 1982–1984
- Prevalence of Diabetes Mellitus and Impaired Glucose Tolerance Among Second-Generation Japanese-American Men
- The Effect of Insulin Treatment on Insulin Secretion and Insulin Action in Type II Diabetes Mellitus
- Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDM
- Prevalence of Diabetes and Impaired Glucose Tolerance and Plasma Glucose Levels in U.S. Population Aged 20–74 Yr
- Global Estimates for Prevalence of Diabetes Mellitus and Impaired Glucose Tolerance in Adults
- Toward Physiological Understanding of Glucose Tolerance: Minimal-Model Approach
- Classification of Obesity with Respect to Morbidity
- Overview of Non‐insulin‐dependent Diabetes Mellitus (NIDDM) in Different Population Groups
Cited by
- Total Fluid Intake and Use of Individual Beverages and Risk of Renal Cell Cancer in Two Large Cohorts
- Vitamin D, Insulin Secretion, Sensitivity, and Lipids
- Functional status of vascular endothelium in diabetes mellitus.
- Improvements in Glycemic Control in Type 2 Diabetes Patients Switched From Sulfonylurea Coadministered With Metformin to Glyburide-Metformin Tablets
- Regulation of Atp10c , a Novel Type 4 P-type ATPase, in 3T3-L1 Mouse Adipocytes
- A comparison of the glycemic index (GI) results obtained from two techniques on a group of healthy and a group of mixed subjects
- Genetic Variation in the Uncoupling Protein and Fatty Acid Binding Protein Gene Families: A Multi-Locus Approach to Investigating Obesity and Type 2 Diabetes
- Neurocognitive implications of diabetes on dementia as measured by an extensive neuropsychological battery.
- Regulation of metabolism and inflammation in liver and skeletal muscle
- Serum insulin, insulin resistance, beta-cell dysfunction, and gallstone disease among type 2 diabetics in Chinese population: a community-based study in Kinmen, Taiwan.
- The use of metabolomics to investigate biomarker profiles as potential early risk factors for development of type ii diabetes mellitus
- A biochemical and functional characterization of diet‐induced brain insulin resistance
- Identification of susceptibility genes in type 2 diabetes.
- Baseline serum 25‐hydroxyvitamin D concentrations in the Tromsø Study 1994–95 and risk of developing type 2 diabetes mellitus during 11 years of follow‐up
- EFEITO DA SOJA E SORGO NO ÍNDICE GLICÊMICO, NA INGESTÃO ALIMENTAR E NA PALATABILIDADE DO SUCO DE MELANCIA EM ADULTOS SAUDÁVEIS
- Relationships between eating quickly and weight gain in Japanese university students: A longitudinal study
- A manutenção do tecido adiposo é fundamental para o controle metabólico do diabetes mellitus induzido em ratos.
- LDL receptor but not apolipoprotein E deficiency increases diet-induced obesity and diabetes in mice.
- The potential role of bacterial metabolic toxins in the development of diabetes
- Dieta hiperlipídica e capacidade secretória de insulina em ratos
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