Hepatic endothelial dysfunction and abnormal angiogenesis: new targets in the treatment of portal hypertension.
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Summary
The modulation of hepatic vascular resistance by correcting the increased hepaticascular tone due to hepatic endothelial dysfunction and correcting the abnormal angiogenesis associated with portal hypertension are focused on.
- Type
- review
- Published
- 2010-09-01
- Cited by
- 221
- References
- 88
- Access
- Open access
- OpenAlex
- https://openalex.org/W2012030428
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:7506686
Keywords
Portal hypertension, Medicine, Splanchnic, Portal venous pressure, Vascular resistance
References
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- Gene transfer of the neuronal NO synthase isoform to cirrhotic rat liver ameliorates portal hypertension.
- Increased Nitric Oxide Bioavailability in Endothelial Cells Contributes to the Pleiotropic Effect of Cerivastatin
- Endothelin‐1–induced vasoconstriction causes a significant increase in portal pressure of rat liver: Localized constrictive effect on the distal segment of preterminal portal venules as revealed by light and electron microscopy and serial reconstruction
- Angiogenesis in health and disease
- Atorvastatin does not exhibit antiviral activity against HCV at conventional doses: A pilot clinical trial
Cited by
- Recombinant human manganese superoxide dismutase reduces liver fibrosis and portal pressure in CCl4-cirrhotic rats.
- Efficacy of carvedilol versus propranolol versus variceal band ligation for primary prevention of variceal bleeding
- Thrombophilic genetic factors PAI-1 4G-4G and MTHFR 677TT as risk factors of alcohol, cryptogenic liver cirrhosis and portal vein thrombosis, in a Caucasian population.
- ULTRASSONOGRAFIA DOPPLER EM CÃES COM HEPATOPATIAS DIFUSAS
- Cellular and Molecular Mechanisms of Novel Therapies to Ameliorate Liver Sinusoidal Dysfunction in Cirrhotic Portal Hypertension
- Endothelin 1 and transforming growth factor-β1 correlate with liver function and portal pressure in cirrhotic patients.
- Pathophysiology and a Rational Basis of Therapy
- The use of vasoconstrictors in patients with liver cirrhosis: how, when, why
- Effects of Sapropterin on Portal and Systemic Hemodynamics in Patients With Cirrhosis and Portal Hypertension: A Bicentric Double-Blind Placebo-Controlled Study
- Coagulation in hepatobiliary disease.
- Obeticholic acid: A new light in the shadows treating portal hypertension?
- Portal hypertension: pathophysiology, diagnosis, and treatment.
- Resolution of liver fibrosis requires myeloid cell–driven sinusoidal angiogenesis
- Diet-induced dyslipidemia leads to nonalcoholic fatty liver disease and oxidative stress in guinea pigs.
- Transplantation of endothelial progenitor cells ameliorates vascular dysfunction and portal hypertension in carbon tetrachloride‐induced rat liver cirrhotic model
- Angiogenesis and Fibrogenesis in Chronic Liver Diseases
- NADPH Oxidase-Derived Peroxynitrite Drives Inflammation in Mice and Human Nonalcoholic Steatohepatitis via TLR4-Lipid Raft Recruitment.
- Hypothyroidism Enhanced Portal Hypertension in a Patient with Alcoholic Liver Cirrhosis, Resulting in the Development of Ascites.
- Management of Portal Hypertension in Children: A Focus on Variceal Bleeding
- Celecoxib Ameliorates Portal Hypertension of the Cirrhotic Rats through the Dual Inhibitory Effects on the Intrahepatic Fibrosis and Angiogenesis
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