TCR repertoires of intratumoral T‐cell subsets
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Summary
Novel methods that are either based on T‐cell receptor (TCR) sequencing or on cancer exome analysis allow the analysis of the tumor reactivity and antigen‐specificity of the intratumoral TCR repertoire with unprecedented detail.
- Type
- review
- Published
- 2014-01-01
- Cited by
- 61
- References
- 64
- OpenAlex
- https://openalex.org/W2011985500
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205212660
Keywords
T-cell receptor, Biology, Repertoire, Immunotherapy, Epitope
References
- High-throughput identification of antigen-specific TCRs by TCR gene capture
- Identification of BING-4 Cancer Antigen Translated From an Alternative Open Reading Frame of a Gene in the Extended MHC Class II Region Using Lymphocytes From a Patient With a Durable Complete Regression Following Immunotherapy
- An Inducible Caspase 9 Safety Switch Can Halt Cell Therapy-Induced Autoimmune Disease1
- Next generation sequencing for TCR repertoire profiling: Platform‐specific features and correction algorithms
- Tumor-specific cytolysis by lymphocytes infiltrating human melanomas.
- Pairing of T‐cell receptor chains via emulsion PCR
- A Novel HLA-A*3303-Restricted Minor Histocompatibility Antigen Encoded by an Unconventional Open Reading Frame of Human TMSB4Y Gene1
- Circulating T cell repertoire complexity in normal individuals and bone marrow recipients analyzed by CDR3 size spectratyping. Correlation with immune status.
- Conditional ligands for Asian HLA variants facilitate the definition of CD8+ T-cell responses in acute and chronic viral diseases
- Identification of specific cytolytic immune responses against autologous tumor in humans bearing malignant melanoma.
- Characterization of the functional specificity of a cloned T-cell receptor heterodimer recognizing the MART-1 melanoma antigen.
- Randomized selection design trial evaluating CD8+-enriched versus unselected tumor-infiltrating lymphocytes for adoptive cell therapy for patients with melanoma.
- Quantitative assessment of T-cell repertoire recovery after hematopoietic stem cell transplantation
- Simultaneous detection of many T-cell specificities using combinatorial tetramer staining
- A safeguard eliminates T cell receptor gene-modified autoreactive T cells after adoptive transfer
- Combinatorial tetramer staining and mass cytometry analysis facilitate T-cell epitope mapping and characterization
- Transfer of a TCR Gene Derived from a Patient with a Marked Antitumor Response Conveys Highly Active T-Cell Effector Functions
- T Cells Targeting Carcinoembryonic Antigen Can Mediate Regression of Metastatic Colorectal Cancer but Induce Severe Transient Colitis.
- Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection.
- The response of autologous T cells to a human melanoma is dominated by mutated neoantigens.
Cited by
- Lymphocytes T CD4 et immunité anti-tumorale naturelle : impact de la chimiothérapie, émergence de lymphocytes T CD4 cytotoxiques
- Sunitinib pretreatment improves tumor-infiltrating lymphocyte expansion by reduction in intratumoral content of myeloid-derived suppressor cells in human renal cell carcinoma
- Immune repertoire: A potential biomarker and therapeutic for hepatocellular carcinoma.
- Personalized approaches to active immunotherapy in cancer.
- Characteristics of Tumor Infiltrating Lymphocyte and Circulating Lymphocyte Repertoires in Pancreatic Cancer by the Sequencing of T Cell Receptors
- Messenger RNA encoding constitutively active Toll‐like receptor 4 enhances effector functions of human T cells
- Identification of characteristic TRB V usage in HBV-associated HCC by using differential expression profiling analysis
- Immune response to cancer therapy: mounting an effective antitumor response and mechanisms of resistance
- A high density of tertiary lymphoid structure B cells in lung tumors is associated with increased CD4+ T cell receptor repertoire clonality
- Adoptive T‐cell therapy for cancer: The era of engineered T cells
- PI3K signalling in inflammation.
- Controls to validate plasma samples for cell free DNA quantification.
- To affinity and beyond: Harnessing the T Cell receptor for cancer immunotherapy
- Engineering T cells for cancer: our synthetic future
- Distinct Profiles of Soluble Cytokine Receptors Between B-Cell Vitreoretinal Lymphoma and Uveitis.
- T cell engineering as therapy for cancer and HIV: our synthetic future
- TCR sequencing facilitates diagnosis and identifies mature T cells as the cell of origin in CTCL
- Role and prognostic importance of regulatory T cells in lung cancer patients, according to the presence of tertiary lymphoid structures
- Clonotypic Diversification of Intratumoral T Cells Following Sipuleucel-T Treatment in Prostate Cancer Subjects
- TIL 2.0: More effective and predictive T‐cell products by enrichment for defined antigen specificities
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