DRUG and LIGHT DOSE DEPENDENCE OF PHOTODYNAMIC THERAPY: A STUDY OF TUMOR and NORMAL TISSUE RESPONSE
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Summary
Reciprocity of drug and light doses for tumor response was shown to exist only at high drug doses, which were not low enough to reduce skin photosensitivity in the authors' models, supported by shielding experiments done to assess the contribution of normal tissue damage to tumor response.
- Type
- article
- Published
- 1987-11-01
- Cited by
- 137
- References
- 15
- OpenAlex
- https://openalex.org/W2011973907
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:21098114
Keywords
Drug, Photosensitivity, Reciprocity (cultural anthropology), Medicine, Drug response
References
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- The structure of the active component of hematoporphyrin derivative.
- Correlation of tumor blood flow to tumor regression after hematoporphyrin derivative (HPD) photodynamic therapy to transplantable bladder tumors.
- Destruction of rat mammary tumor and normal tissue microcirculation by hematoporphyrin derivative photoradiation observed in vivo in sandwich observation chambers.
- In vitro and in vivo light dose rate effects related to hematoporphyrin derivative photodynamic therapy.
- Determination of [3H]- and [14C]hematoporphyrin derivative distribution in malignant and normal tissue.
- Tumor destruction and kinetics of tumor cell death in two experimental mouse tumors following photodynamic therapy.
- Photoradiation therapy. II. Cure of animal tumors with hematoporphyrin and light.
- Photocytotoxicity in vivo of haematoporphyrin derivative components.
- Tumour microcirculation as a target for hyperthermia.
- INTERDEPENDENCE OF FLUENCE, DRUG DOSE and OXYGEN ON HEMATOPORPHYRIN DERIVATIVE INDUCED PHOTOSENSITIZATION OF TUMOR MITOCHONDRIA
- PHOTOBLEACHING OF PORPHYRINS USED IN PHOTODYNAMIC THERAPY AND IMPLICATIONS FOR THERAPY
- DRUG AND LIGHT DOSE DEPENDENCE OF PHOTODYNAMIC THERAPY: A STUDY OF TUMOR CELL CLONOGENICITY AND HISTOLOGIC CHANGES
- Photosensitization of malignant tumors.
Cited by
- SINGLET OXYGEN GENERATION OF PORPHYRINS, CHLORINS, AND PHTHALOCYANINES
- Tumor versus vascular photodamage in a rat tumor model.
- Étude du protocole d'illumination sur le métabolisme tumoral en thérapie photodynamique du cancer à l'aide de l'imagerie tomographique d'émission par positrons
- The role of light-emitting diodes for photodynamic therapy of brain tumors
- Análise da necrose em tecidos normais fotossensibilizados pós terapia fotodinâmica - estudo in vivo
- Tissue localization of photosensitizers and the mechanism of photodynamic tissue destruction.
- An in vivo quantitative structure-activity relationship for a congeneric series of pyropheophorbide derivatives as photosensitizers for photodynamic therapy.
- Inhibition of cyclooxygenase-2 indirectly potentiates antitumor effects of photodynamic therapy in mice.
- Photodynamic therapy (PDT) of cancer: from local to systemic treatment
- Photodynamic therapy using a protoporphyrinogen oxidase inhibitor.
- Fluorescence detection of tumors early diagnosis of microscopic lesions in preclinical studies
- The effect of therapy on tumour vascular function.
- In vivo uptake and biodistribution of lipophilic and hydrophilic photosensitizers
- Photodynamic therapy as an adjuvant intraoperative treatment of recurrent head and neck carcinomas
- Skin Necrosis due to Photodynamic Action of Benzoporphyrin Depends on Circulating Rather than Tissue Drug Levels: Implications for Control of Photodynamic Therapy
- Photofrin photodynamic therapy: 2.0 mg/kg or not 2.0 mg/kg that is the question.
- RAPID UPREGULATION OF CYTOPROTECTIVE NITRIC OXIDE IN BREAST TUMOR CELLS SUBJECTED TO A PHOTODYNAMIC THERAPY-LIKE OXIDATIVE CHALLENGE
- LIPOSOMAL DELIVERY OF A PHOTOSENSITIZER, BENZOPORPHYRIN DERIVATIVE MONOACID RING A (BPD), TO TUMOR TISSUE IN A MOUSE TUMOR MODEL
- Intra‐abdominal photodynamic therapy: From theory to feasibility
- Predictive dosimetry for threshold phototoxicity in photodynamic therapy on normal skin: red wavelengths produce more extensive damage than blue at equal threshold doses.
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