Metformin effects on clinical features, endocrine and metabolic profiles, and insulin sensitivity in polycystic ovary syndrome: a randomized, double-blind, placebo-controlled 6-month trial, followed by open, long-term clinical evaluation.
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Summary
In women with PCOS metformin treatment reduced hyperinsulinemia and hyperandrogenemia, independently of changes in body weight, and logistic regression analysis of baseline characteristics showed that plasma insulin, serum androstenedione, and menstrual history were independent predictors of the treatment's clinical efficacy.
- Type
- article
- Published
- 2000-06-01
- Cited by
- 795
- References
- 37
- Access
- Open access
- OpenAlex
- https://openalex.org/W2011754459
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:42986582
Keywords
Medicine, Metformin, Polycystic ovary, Internal medicine, Endocrinology
References
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- Assessment of insulin sensitivity in vivo.
- Insulin infusion amplifies 17 alpha-hydroxycorticosteroid intermediates response to adrenocorticotropin in hyperandrogenic women: apparent relative impairment of 17,20-lyase activity.
- Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia, and systolic blood pressure, while facilitating normal menses and pregnancy.
- 17 alpha-Hydroxyprogesterone responses to leuprolide and serum androgens in obese women with and without polycystic ovary syndrome offer dietary weight loss.
- Improvement in endocrine and ovarian function during dietary treatment of obese women with polycystic ovary syndrome.
- The insulin resistance in women with hyperandrogenism is partially reversed by antiandrogen treatment: evidence that androgens impair insulin action in women.
- A direct effect of hyperinsulinemia on serum sex hormone-binding globulin levels in obese women with the polycystic ovary syndrome.
- Menstrual Cyclicity After Metformin Therapy in Polycystic Ovary Syndrome
- Effects of sex steroids on serum lipids and lipoproteins.
- Insulin resistance and lipid metabolism.
- Decreases in ovarian cytochrome P450c17 alpha activity and serum free testosterone after reduction of insulin secretion in polycystic ovary syndrome.
- Inhibitory effect of sandostatin on secretion of luteinising hormone and ovarian steroids in polycystic ovary syndrome
- Insulin-sensitising agents in polycystic-ovary syndrome.
- Effects of diet and metformin administration on sex hormone-binding globulin, androgens, and insulin in hirsute and obese women.
- Suppression of serum insulin by diazoxide reduces serum testosterone levels in obese women with polycystic ovary syndrome.
- Effects of metformin on insulin secretion, insulin action, and ovarian steroidogenesis in women with polycystic ovary syndrome.
Cited by
- Aspetti medico-legali della somministrazione di antiandrogeni nella donna
- Minimal response of circulating lipids in women with polycystic ovary syndrome to improvement in insulin sensitivity with troglitazone.
- N-acetyl-cysteine is a novel adjuvant to clomiphene citrate in clomiphene citrate-resistant patients with polycystic ovary syndrome.
- Prevalence of insulin resistance in the polycystic ovary syndrome using the homeostasis model assessment.
- Endocrine and metabolic effects of rosiglitazone in overweight women with PCOS: a randomized placebo-controlled study.
- Polycystic ovary syndrome update in adolescence
- The effect of metformin treatment in vivo on acute and long-term energy metabolism and progesterone production in vitro by granulosa cells from women with polycystic ovary syndrome
- Comparison of metformin versus rosiglitazone in patients with Acanthosis nigricans: a pilot study.
- Insulin resistance and fertility in polycystic ovary syndrome.
- Polycystic Ovary Syndrome in Adolescents
- Polycystic ovary syndrome: a major unrecognized cardiovascular risk factor in women.
- Polycystic Ovary (Stein-Leventhal) Syndrome: Etiology, Complications, and Treatment
- Thiazolidinediones for the Therapeutic Management of Polycystic Ovary Syndrome
- Amenorrhea: an approach to diagnosis and management.
- Polycystic ovarian syndrome: ovulation induction
- A review of thiazolidinediones and metformin in the treatment of type 2 diabetes with focus on cardiovascular complications
- THE GENETICS OF INSULIN RESISTANCE IN FAMILIES WITH POLYCYSTIC OVARY SYNDROME
- Eine interdisziplinäre Herausforderung
- Polycystic ovary syndrome - Metformin treatment in pregnancy
- Androgens in Health and Disease
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