Effects of methotrexate on established cell lines of human choriocarcinoma.
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Summary
The deleterious effects of MTX observed in both the BeWo and Jar cell lines were consistent with the suggestion that the major effect of the drug is to inhibit dihydrofolate reductase.
- Type
- article
- Published
- 1972-10-01
- Cited by
- 22
- References
- 16
- OpenAlex
- https://openalex.org/W2011527232
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:35424759
Keywords
Incubation, Thymidine, Deoxyuridine, Methotrexate, Trichloroacetic acid
References
- Antagonists and nucleic acids
- Folic acid coenzymes in the biosynthesis of purines and pyrimidines.
- Current cancer chemotherapy in obstetrics and gynecology.
- On the poor correlation between the inhibition by methotrexate of dihydrofolate reductase and of deoxynucleoside incorporation into DNA.
- Simultaneous measurement of RNA, DNA, and protein synthesis in mouse tumor and reticuloendothelial tissue slices using glucose-6-3H as a common precursor.
- Effects of hormones, methotrexate, and dactinomycin on benign trophoblast.
- CHEMOTHERAPY IN WOMEN WITH TROPHOBLASTIC DISEASE: CHORIOCARCINOMA, CHORIOADENOMA DESTRUENS, AND COMPLICATED HYDATIDIFORM MOLE
- THE HORMONE‐SYNTHESIZING TROPHOBLASTIC CELL IN VITRO: A MODEL FOR CANCER RESEARCH AND PLACENTAL HORMONE SYNTHESIS
- The establishment of a cell line of human hormone-synthesizing trophoblastic cells in vitro.
- Folic acid antagonists.
- A malignant trophoblastic cell line: high rates of DNA synthesis measured by a rapid disc method.
- Choriocarcinoma of Women Maintained in Serial Passage in Hamster and Rat
- S-phase cells of rapidly growing and resting populations. Differences in response to methotrexate.
- The effect of methotrexate and dactinomycin on transplantable malignant and benign trophoblastic growths.
- The JAr cell line - continuous human multi-hormone production and controls
Cited by
- Assay of anti-cancer drugs in tissue culture: conditions affecting their ability to incorporate 3H-leucine after drug treatment.
- The stimulation by methotrexate of human chorionic gonadotropin and placental alkaline phosphatase in cultured choriocarcinoma cells.
- Chemotherapy of human choriocarcinoma transplanted to nude mice.
- Morphological differentiation of human choriocarcinoma cells induced by methotrexate.
- Effect of methotrexate on the growth and human chorionic gonadotropin secretion of human choriocarcinoma cell lines in vitro.
- Trophoblastic cell sensitivity to 8-day chemotherapy in nonmetastatic gestational trophoblastic neoplasia.
- Correlation of plasma methotrexate concentration with human chorionic gonadotropin and therapeutic response to low-dose methotrexate-citrovorum factor in low-medium-risk gestational trophoblastic tumors.
- Methotrexate inhibition of normal trophoblasts in vitro.
- Drug-induced biochemical markers of cancer in cervical carcinoma cells.
- Ectopic production in serum-free media of the common alpha subunit of the glycoprotein hormones
- Failure of single dose methotrexate followed by citrovorum factor in nonmetastatic gestational trophoblastic neoplasia.
- Cell biology of choriocarcinoma.
- Study on formulation variables of methotrexate loaded mesoporous MCM-41 nanoparticles for dissolution enhancement.
- Serum methotrexate and human chorionic gonadotropin concentrations during five‐day chemotherapy for low‐risk metastatic gestational trophoblastic neoplasia
- Effects of pregnenolone, cyanoketone, and equilenin on the human malignant trophoblast in vitro
- Effects of antimicrotubule agents, potassium and inhibitors of energy production on hCG secretion
- Chorionic gonadotrophin and c-myc expression in growing and growth-inhibited (intermediate) trophoblasts.
- Inhibition of methotrexate-induced differentiation of cultured human choriocarcinoma (BeWo) cells by thymidine.
- The Stimulationby Methotrexate of HumanChorionic Gonadotropinand Placental Alkaline Phosphatasein CulturedChoriocarcinomaCells
- Proteomic biomarker discovery for preeclampsia
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