The Rab6-regulated KIF1C kinesin motor domain contributes to Golgi organization
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Summary
A novel function for KIF1C is reported: it transports Rab6A-vesicles and can influence Golgi complex organization, which represents an entirely new mode of regulation for a kinesin motor, and likely has important consequences for Kif1C's cellular functions.
- Type
- article
- Published
- 2015-03-30
- Cited by
- 45
- References
- 65
- Access
- Open access
- OpenAlex
- https://openalex.org/W2011485482
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:1952609
Keywords
Kinesin, Golgi apparatus, Motor protein, Cell biology, Microtubule
References
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- Traffic control: regulation of kinesin motors
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- Cargo-selective endosomal sorting for retrieval to the Golgi requires retromer
- Effects of Mutations in the γ-Phosphate Binding Site of Myosin on Its Motor Function*
- The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes.
- Bicaudal d family adaptor proteins control the velocity of Dynein-based movements.
- A Versatile Nanotrap for Biochemical and Functional Studies with Fluorescent Fusion Proteins*S
- Functions of unconventional myosins.
- Electrostatically Biased Binding of Kinesin to Microtubules
Cited by
- Molecular Biology of the Cell
- Rab6 Is Required for Multiple Apical Transport Pathways but Not the Basolateral Transport Pathway in Drosophila Photoreceptors
- Coordination of autophagosome–lysosome fusion and transport by a Klp98A–Rab14 complex in Drosophila
- Membrane traffic during axon development
- Getting membrane proteins on and off the shuttle bus between the endoplasmic reticulum and the Golgi complex
- Transport Vesicle Tethering at the Trans Golgi Network: Coiled Coil Proteins in Action
- Rab GTPase signaling in neurite outgrowth and axon specification
- Involvement of ARHGEF10, GEF for RhoA, in Rab6/Rab8-mediating membrane traffic
- Intracellular Cargo Transport by Kinesin-3 Motors
- Rab proteins as major determinants of the Golgi complex structure
- Consequences of Rab GTPase dysfunction in genetic or acquired human diseases
- Cell-matrix adhesion controls Golgi organization and function through Arf1 activation in anchorage-dependent cells
- Rab and Arf proteins at the crossroad between membrane transport and cytoskeleton dynamics.
- Progressive ataxia of Charolais cattle highlights a role of KIF1C in sustainable myelination
- Kinesin Family of Proteins Kif11 and Kif21B Act as Inhibitory Constraints of Excitatory Synaptic Transmission Through Distinct Mechanisms
- Activation of intracellular transport by relieving KIF1C autoinhibition
- HOOK3 is a scaffold for the opposite-polarity microtubule-based motors cytoplasmic dynein and KIF1C
- Rab6 regulates cell migration and invasion by recruiting Cdc42 and modulating its activity
- PTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport
- Cell-matrix adhesion controls Golgi organization and function by regulating Arf1 activation in anchorage dependent cells
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