Transition of localization of the N-Myc protein from nucleus to cytoplasm in differentiating neurons.
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Summary
Investigation of N-Myc protein expression in embryonic neural tissues found that the protein was usually localized in the nucleus, but accumulated in the cytoplasm upon differentiation of specific classes of neurons, e.g., retinal ganglion cells, neurons of spinal ganglia, and Purkinje cells of the cerebellum.
- Type
- article
- Published
- 1993-01-01
- Cited by
- 126
- References
- 34
- OpenAlex
- https://openalex.org/W2011330893
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:12502354
Keywords
Cytoplasm, Nucleus, Biology, Cell biology, Cerebellum
References
- Cloning and expression of a chicken c-rel cDNA: unlike p59v-rel, p68c-rel is a cytoplasmic protein in chicken embryo fibroblasts.
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- Translocation of a store of maternal cytoplasmic c-myc protein into nuclei during early development
- N-myc down regulates neural cell adhesion molecule expression in rat neuroblastoma
- Episome-generated N-myc antisense RNA restricts the differentiation potential of primitive neuroectodermal cell lines
- Subnuclear localization and antitransforming activity of N-myc:beta-galactosidase fusion proteins
- Rapid and transient decrease of N-myc expression in retinoic acid-induced differentiation of OTF9 teratocarcinoma stem cells.
- Organization and expression of the chicken N-myc gene
- Identification and characterization of the protein encoded by the human N-myc oncogene.
- Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-κB transcription factor
- Contrasting patterns of myc and N-myc expression during gastrulation of the mouse embryo.
- N-myc proto-oncogene expression during organogenesis in the developing mouse as revealed by in situ hybridization
- Transposition and amplification of oncogene-related sequences in human neuroblastomas.
- Alternative Forms of Max as Enhancers or Suppressors of Myc-Ras Cotransformation
- Expression of N-myc in teratocarcinoma stem cells and mouse embryos
- Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour
- Nuclear localization of c-Fos, but not v-Fos proteins, is controlled by extracellular signals.
- Detection of brain-derived neurotrophic factor-like activity in fibroblasts and Schwann cells: inhibition by antibodies to NGF.
- Association of Myn, the murine homolog of max, with c-Myc stimulates methylation-sensitive DNA binding and ras cotransformation.
- A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo.
Cited by
- Neural cell adhesion molecules in activity-dependent development and synaptic plasticity.
- The Expression of Plasma Membrane Ca2+ Pump Isoforms in Cerebellar Granule Neurons Is Modulated by Ca2+ *
- The Myc/Max/Mad network and the transcriptional control of cell behavior.
- Cooperative action of Sox9, Snail2 and PKA signaling in early neural crest development
- The myc oncogene: MarvelouslY Complex.
- Circadian and efferent modulation of visual sensitivity.
- Proteins of the Myc network: essential regulators of cell growth and differentiation.
- Prevention of Apoptotic Neuronal Death by G Ganglioside
- From receptor internalization to nuclear translocation. New targets for long-term pharmacology.
- Differentiation and transdifferentiation of the retinal pigment epithelium.
- The Mlx network: evidence for a parallel Max-like transcriptional network that regulates energy metabolism.
- Human tau filaments induce microtubule and synapse loss in an in vivo model of neurofibrillary degenerative disease.
- c‐Myc expression in human anagen hair follicles
- Sfrp1 and Sfrp2 regulate anteroposterior axis elongation and somite segmentation during mouse embryogenesis
- Increased expression of the alpha subunit of the ciliary neurotrophic factor (CNTF) receptor by rat racial motoneurons after neonatal axotomy and CNTF treatment.
- Synaptic proteins and the assembly of synaptic junctions.
- Increased progenitor proliferation and apoptotic cell death in the sensory lineage of mice overexpressing N-myc
- Action of protein kinase A activators on the caudal neuromuscular junction of toad tadpoles, recorded on synaptic spots.
- An alternative pathway for gene regulation by Myc
- N-myc-dependent repression of ndr1, a gene identified by direct subtraction of whole mouse embryo cDNAs between wild type and N-myc mutant.
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