Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation.
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Summary
Recent progress on drug metabolism activity profiles, interindividual variability and regulation of expression, and the functional and clinical impact of genetic variation in drug metabolizing P450s are reviewed.
- Type
- review
- Published
- 2013-04-01
- Cited by
- 3,819
- References
- 603
- Access
- Open access
- OpenAlex
- https://openalex.org/W2010427019
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:24631027
Keywords
Drug metabolism, Cytochrome P450, CYP3A4, Pharmacogenetics, Biology
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- Inhibitory Effects of Eight Green Tea Catechins on Cytochrome P450 1A2, 2C9, 2D6, and 3A4 Activities.
- Non-Alcoholic Fatty Liver Disease (NAFLD) - Pathogenesis, Classification, and Effect on Drug Metabolizing Enzymes and Transporters
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- CYP3A4 Mediates Oxidative Metabolism of the Synthetic Cannabinoid AKB-48
- Influence of CYP2D6 and CYP2C19 genetic polymorphism on the pharmacokinetics of tolperisone in healthy volunteers
- ZHX2 REGULATION OF LIPID METABOLISM AND THE BALANCE BETWEEN CARDIOVASCULAR AND HEPATIC HEALTH