Multiple promoters direct tissue-specific expression of the rat BDNF gene.
Explore this paper's citation graph
Summary
The data demonstrate that alternative usage of four promoters within the BDNF gene and differential splicing control tissue-specific and seizure-induced expression of BDNF mRNA.
- Type
- article
- Published
- 1993-03-01
- Cited by
- 879
- References
- 70
- OpenAlex
- https://openalex.org/W2010050518
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:44521942
Keywords
Exon, Promoter, Biology, Polyadenylation, Alternative splicing
References
- A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.
- Alternative promoters in developmental gene expression.
- The mouse carbonic anhydrase I gene contains two tissue-specific promoters
- Sequences within the 5'-flanking region of the S14 gene confer responsiveness to glucose in primary hepatocytes.
- Translational discrimination of mRNAs coding for human insulin-like growth factor II.
- Purification of a new neurotrophic factor from mammalian brain.
- Separate promoters control transcription of the human aminopeptidase N gene in myeloid and intestinal epithelial cells.
- Differential association of insulin-like growth factor I mRNA variants with polysomes in vivo.
- Brain-derived neurotrophic factor supports the survival of cultured rat retinal ganglion cells
- Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non‐NMDA glutamate receptors.
- Mouse nerve growth factor gene: structure and expression
- Regional distribution of brain‐derived neurotrophic factor mRNA in the adult mouse brain.
- Organization and expression of eucaryotic split genes coding for proteins.
- A common silencer element in the SCG10 and type II Na+ channel genes binds a factor present in nonneuronal cells but not in neuronal cells.
- Expression of the rat growth hormone-releasing hormone gene in placenta is directed by an alternative promoter.
- CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements
- BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra
- Silencing the type II sodium channel gene: a model for neural-specific gene regulation.
- Cloning and expression of a cDNA encoding a novel human neurotrophic factor
- Hippocampal damage and kainic acid injection induce a rapid increase in mRNA for BDNF and NGF in the rat brain.
Cited by
- Two Promoters Direct Transcription of the Mouse NT‐3 Gene
- Up-regulation of brain-derived neurotrophic factor expression by brimonidine in rat retinal ganglion cells.
- The excitoprotective effect of N‐methyl‐d‐aspartate receptors is mediated by a brain‐derived neurotrophic factor autocrine loop in cultured hippocampal neurons
- Robust stimulation of TrkB induces delayed increases in BDNF and Arc mRNA expressions in cultured rat cortical neurons via distinct mechanisms
- Environmental regulation of the neural epigenome.
- BDNF-Live-Exon-Visualization (BLEV) Allows Differential Detection of BDNF Transcripts in vitro and in vivo
- The role of neurotrophins related to stress in saliva and salivary glands.
- Mechanism Of Gaba b Receptor-Activated Increases In L-Type Calcium Current In The Neonatal Mammalian Hippocampus
- Huntington's disease.
- Brain Derived Neurotrophic Factor (BDNF) mRNA Expression Levels in Mice Exposed to Learned Helplessness
- The role of muscle-synthesized brain-derived neurotrophic factor (BDNF) in the health and maintenance of motorneurons
- Regulation of brain-derived neurotrophic factor expression in neurons.
- A Role for Histone Modification in the Mechanism of Action of Antidepressant and Stimulant Drugs: a Dissertation
- Fibrinolytic Proteins and Brain-Derived Neurotrophic Factor Modulation of Suprachiasmatic Nucleus Circadian Clock
- Metilfenidato causa alterações neuroquímicas e comportamentais em ratos
- New pharmacological treatment approaches for anxiety disorders.
- Regulation of neurotrophin expression and activity in the retina.
- BDNF and synaptic plasticity, cognitive function, and dysfunction.
- Alternative Polyadenylation in CD2 Expression
- Genetic and Epigenetic Regulation of the Brain-Derived Neurotrophic Factor in the Central Nervous System
Related papers
- Characterization of Specific Protein-RNA Complexes Associated with the Coupling of Polyadenylation and Last-Intron Removal
- Polyadenylation of Friend murine leukemia virus env‐mRNA is affected by its splicing
- Mutation of the AAUAAA polyadenylation signal depresses in vitro splicing of proximal but not distal introns.
- Stage-specific changes in SR splicing factors and alternative splicing in mammary tumorigenesis
- Alternative Splicing and Isoforms: From Mechanisms to Diseases
- Interplay between Alternative Splicing and Alternative Polyadenylation Defines the Expression Outcome of the Plant Unique OXIDATIVE TOLERANT-6 Gene
- RBM25/LUC7L3 function in Cardiac Sodium Channel Splicing Regulation of Human Heart Failure
- Neuron-specific splicing.
- Cellular signals modulate alternative splicing.
- Alternative Isoform Regulation in Human Tissue Transcriptomes