Structural mechanism of RNA recognition by the RIG-I-like receptors.
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Summary
The mechanism of the RLRs' sensing of nonself RNA is discussed and three functional domains of RLRs are defined, providing insights into how RLRs function as a molecular switch through interactions with virus-specific RNA ligands.
- Type
- review
- Published
- 2008-08-15
- Cited by
- 276
- References
- 22
- Access
- Open access
- OpenAlex
- https://openalex.org/W2009708031
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:205410474
Keywords
Biology, RNA, RIG-I, Mechanism (biology), Cell biology
References
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- 5'-Triphosphate RNA Is the Ligand for RIG-I
- Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
- Processing of Genome 5′ Termini as a Strategy of Negative-Strand RNA Viruses to Avoid RIG-I-Dependent Interferon Induction
- Nonself RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses.
- Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus.
- Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2
- Structure and Function of LGP2, a DEX(D/H) Helicase That Regulates the Innate Immunity Response*
- Shared and Unique Functions of the DExD/H-Box Helicases RIG-I, MDA5, and LGP2 in Antiviral Innate Immunity1
- Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5
- Cell type-specific involvement of RIG-I in antiviral response.
- The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
- Structural Basis of Toll-Like Receptor 3 Signaling with Double-Stranded RNA
- Antiviral Actions of Interferons
- Molecular biology of picornaviruses
- Possible Unifying Mechanism of Picornavirus Genome Replication
Cited by
- EGFR is Essential for TLR3 Signaling
- Structural basis of viral RNA recognition by RIG-I-like receptors
- Pattern Recognition Receptor-Dependent Mechanisms of Acute Lung Injury
- CHARACTERIZATION OF THE ROLES OF TWO REGULATORS OF VIRUS INFECTION: GP78 AND BPIFB3
- Étude de la physiopathologie de l'infection Chikungunya en phase aiguë et chronique chez l'homme
- The effects of toll-like receptor ligand-activated dendritic cells on human CD4+ T cell responses
- Nouveaux régulateurs de la signalisation TLR2-NF-kB
- Functional characterization of NLRC3
- Understanding how injured tissue communicates with the immune system
- Collaboration of Toll-like and RIG-I-like receptors in human dendritic cells: tRIGgering antiviral innate immune responses.
- Sensors of Infection: Viral Nucleic Acid PRRs in Fish
- Zur Rolle des langen Pentraxins PTX3 in der Pathogenese des Systemischen Lupus Erythematodes
- Role of HCV F/ARF protein and NAD(P)H oxidases in the RIG-I/MDA5-mediated interferon response in hepatocytes
- UXT-V1 Facilitates the Formation of MAVS Antiviral Signalosome on Mitochondria
- FCRN MEDIATED MUCOSAL IMMUNITY AND SUBUNIT VACCINE DELIVERY
- Role of Toll-like receptors and retinoic acid inducible gene I in endogenous production of type I interferon in dermatomyositis.
- Neutrophils Counteract Autophagy-Mediated Anti-Inflammatory Mechanisms in Alveolar Macrophage: Role in Post-Hemorrhagic Shock Acute Lung Inflammation
- A Role for APPL1 in TLR3/4-Dependent TBK1 and IKKε Activation in Macrophages
- Regulation of NF-κB by the CARD proteins
- Retinoic acid-inducible gene-I-like receptor (RLR)-mediated antiviral innate immune responses in the lower respiratory tract: Roles of TRAF3 and TRAF5.
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