Myocardial protection by PJ34, a novel potent poly (ADP-ribose) synthetase inhibitor.
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Summary
The results suggest that PJ34 provides cardioprotection by decreasing myocardial infarct size and enhancing postischemic regional and global functional recovery.
- Type
- article
- Published
- 2002-02-01
- Cited by
- 69
- References
- 25
- Access
- Open access
- OpenAlex
- https://openalex.org/W2009556085
- Semantic Scholar
- https://api.semanticscholar.org/CorpusID:986458
Keywords
Medicine, Cardioprotection, Reperfusion injury, Cardiology, Ischemia
References
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- Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation
- Inhibition of poly (ADP-ribose) Synthetase Attenuates Neutrophil Recruitment and Exerts Antiinflammatory Effects
- Poly (ADP-ribose) synthetase mediates intestinal mucosal barrier dysfunction after mesenteric ischemia.
- Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle.
- Poly(ADP‐Ribose) Synthase Inhibition Reduces Ischemic Injury and Inflammation in Neonatal Rat Brain
- Reactive oxygen injury to cultured pulmonary artery endothelial cells: mediation by poly(ADP-ribose) polymerase activation causing NAD depletion and altered energy balance.
- Controlled reperfusion after lung ischemia: implications for improved function after lung transplantation.
- Peroxynitrite‐induced thymocyte apoptosis: the role of caspases and poly (ADP‐ribose) synthetase (PARS) activation
- Effect of genetic disruption of poly (ADP-ribose) synthetase on delayed production of inflammatory mediators and delayed necrosis during myocardial ischemia-reperfusion injury.
- DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite.
- Adenosine-enhanced ischemic preconditioning decreases infarct in the regional ischemic sheep heart.
- Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase.
- Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion.
- Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide.
- Genetic disruption of poly (ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia/reperfusion injury.
- Myocardial Ischemic Preconditioning in Rodents Is Dependent on Poly (ADP-Ribose) Synthetase
- Cellular responses to DNA damage in the absence of Poly(ADP-ribose) polymerase.
Cited by
- Inhibition of the activity of poly (ADP-ribose) polymerase reduces heart ischaemia/reperfusion injury via suppressing JNK-mediated AIF translocation
- Characterization and Quantification of Poly(ADP-Ribose) in Cells and Tissues by Isotope Dilution Mass Spectrometry
- Cardioprotective effects of poly(ADP-ribose) polymerase inhibition.
- Vincristine Attenuates N-methyl-N′-nitro-N-nitrosoguanidine-Induced Poly-(ADP) Ribose Polymerase Activity in Cardiomyocytes
- THERAPEUTIC INJECTION OF PARP INHIBITOR INO-1001 PRESERVES CARDIAC FUNCTION IN PORCINE MYOCARDIAL ISCHEMIA AND REPERFUSION WITHOUT REDUCING INFARCT SIZE
- PARP-1 expression and activity in primary human lung cells
- Poly(ADP-ribose) polymerase-1 (PARP-1) and its therapeutic implications.
- DNA damage repair and cardiovascular diseases.
- Role of poly(ADP-ribose) polymerase activation in endotoxin-induced cardiac collapse in rodents.
- Evolution of poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. From concept to clinic.
- Poly(ADP-ribose) polymerase-1 is involved in the neuronal death induced by quinolinic acid in rats.
- Systemic and Hepatosplanchnic Hemodynamic and Metabolic Effects of the PARP Inhibitor PJ34 During Hyperdynamic Porcine Endotoxemia
- A randomized, placebo-controlled trial to evaluate the tolerability, safety, pharmacokinetics, and pharmacodynamics of a potent inhibitor of poly(ADP-ribose) polymerase (INO-1001) in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention: results of th
- Role of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: the therapeutic potential of PARP inhibitors.
- Therapeutic Applications of PARP Inhibitors: Anticancer Therapy and Beyond
- Synthesis and in vivo evaluation of [11C]PJ34, a potential radiotracer for imaging the role of PARP-1 in necrosis.
- Oxidant-induced cardiomyocyte injury: identification of the cytoprotective effect of a dopamine 1 receptor agonist using a cell-based high-throughput assay.
- Poly(ADP-ribose) polymerases: homology, structural domains and functions. Novel therapeutical applications.
- THE PARP-1 INHIBITOR INO-1001 FACILITATES HEMODYNAMIC STABILIZATION WITHOUT AFFECTING DNA REPAIR IN PORCINE THORACIC AORTIC CROSS-CLAMPING-INDUCED ISCHEMIA/REPERFUSION
- PJ34, a poly adenosine diphosphate-ribose polymerase inhibitor, attenuates chromate-induced nephrotoxicity.
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